Severe courses of infection with SARS-CoV-2 are characterized not only by strong immune activation and inflammatory reactions, but above all by dysfunction of the vascular system.
Project proposal in the key area of "Pathophysiology: Immunomodulation and Control" of the COFONI research network supported by the state of Lower Saxony is now successfully funded.
An international research team led by DZL scientists Professor Dr. Danny Jonigk and Christopher Werlein was able to demonstrate changes in blood vessels caused by infection with SARS-CoV-2.
Successful collaboration of scientists from the German Centers for Lung Research (DZL), Infection Research (DZIF) and Cardiovascular Research (DZHK) elucidates mechanism of brain damage in SARS-CoV-2 infection.
From 29-30 September 2021, the DZL Academy hosted their first symposium entitled "When bugs hit the lung - infections as drivers of acute deterioration of lung disease".
Scientists of the DZL site network UGMLC have discovered that the substance thapsigargin inhibits the proliferation of SARS-CoV-2.
Children can also be infected with the novel coronavirus SARS-CoV-2, but have a substantially lower risk for developing severe COVID-19 disease compared to adults.
COVID-19 disease severity is determined by the individual patient’s immune response. The precise mechanisms taking place inside the lungs and blood during the early phase of the disease remain unclear.