Diffuse Parenchymal Lung Disease (DPLD)

Science and Research

The Diffuse Parenchymal Lung Disease (DPLD) core dataset represents the most important lung research parameters for the disease area.

Kategorie	Parameter	Value Set	Description
Biometric Data	Gender	Diverse Female Male
Biometric Data	Age at visit
Biometric Data	Weight
Biometric Data	Height
Biometric Data	BMI
Health Questionnaires	MRC	MRC Grade 1 MRC Grade 2 MRC Grade 3 MRC Grade 4 MRC Grade 5
Health Questionnaires	Cough visual analogue score	Number from 0 to 100
Health Questionnaires	EQ-5D VISUAL ANALOG SCORE	Number from 0 to 100
Smoking History	Smoking Status	Ex Smoker Passive Smoker Active Smoker Never Smoker
Smoking History	Amount	Packyears Zigaretten/Tag
Comorbidities	Comorbidities
Lung Function	FEV1 observed value		Forced Expiratory Volume in 1 second: the volume of air that has been exhaled at the end of the first second of forced expiration
Lung Function	TLC observed value		Total Lung Capacity: the volume of air in the lungs at maximum inflation
Lung Function	VC observed value		Vital Capacity: the largest volume a patient can exhale after a full inhalation
Lung Function	FVC observed value		Forced Vital Capacity: the volume of air that can forcibly be blown out after full inspiration
Lung Function	RV observed value		Residual Volume: the amount of air remaining in the lungs after maximum exhalation
Lung Function	RV%TLC observed value		Residual Volume as percentage of the Total Lung Capacity
Lung Function	DLCO SB corrected for Hb + alveolar ventilation (KCO)		Diffusion Capacity: the carbon monoxide uptake from a single inspiration in a standard time (usually 10 sec)
Blood Gas Analysis	Capillary SaO2		Oxygen saturation in capillary blood
Blood Gas Analysis	Capillary pO2		Partial pressure of oxygen in capillary blood
Blood Gas Analysis	Capillary pCO2		Partial pressure of carbon dioxide in capillary blood
Blood Gas Analysis	Pulse oximetry: SaO2
Exercise Testing	6MWT distance
Exercise Testing	Number of sit-ups in one minute
Spiroergometry	VO2 max		Maximum oxygen uptake
Echocardiography	Tricuspid insufficiency	I° II° III° IV°
Echocardiography	RA & RV enlargement
Echocardiography	sPAP		Systolic Pulmonary Arterial Pressure (sPAP)
Echocardiography	TAPSE		Tricuspid Annular Plane Systolic Excursion is a highly sensitive and specific parameter of global right ventricular (RV) function which describes apex-to-base shortening.
Diagnosis	MDT diagnosis based on:	Radiographic data Pathological data Clinical data
Diagnosis	DPLD Diagnosis	Neurofibromatosis ILD Unclassifiable ILD Desquamative Interstitial Pneumonia (DIP) Lymphangioleiomyomatosis (LAM) Cryptogenic Organizing Pneumonia (COP) Systemic Sclerosis Non-specific Interstitial Pneumonia (NSIP) ILD due to inhaled organic substances Respiratory Bronchitis ILD Any rare ILD not listed above Hypersensitivity pneumonitis Ankylosing spondylitis (Bechterew's disease) Unclassifiable CVD-ILD Aspiration pneumonia ILD in the context of inflammatory bowel disease Lymphoid Interstitial Pneumonia (LIP) ILD due to medical measures Acute Interstitial Pneumonia (AIP) Common variable immunodeficiency syndrome (CVID) - ILD Sjögren's Disease Polymyositis/Dermatomyositis Chronic eosinophilic pneumonia (CEP) IgG4-related disease Granulomatosis with polyangiitis (GPA) Unclassifiable IIP Nieman Pick Disease Hermansky-Pudlack syndrome Idiopathic pulmonary fibrosis Mixed Connective Tissue Disease (Sharp's syndrome) Acute eosinophilic pneumonia (AEP) Amyloidosis Idiopathic Pleuroparenchymal Fibroelastosis (IPPFE) Unclassifiable IIP Meets IPAF criteria? Pulmonary Langerhans Cell Histioystosis (LCH) Gauchers's Disease Pulmonary alveolar proteinosis (PAP) Behcet's Disease Acute Fibrinous and Organizing Pneumonia (AFOP) Sarcoidosis ILD due to inhaled anorganic substances Lupus erythematosus ILD due to drugs (acc. to pneumotox) Rheumatoid Arthritis (RA) Bronchiolocentric granulomatosis Bronchiolocentric form of IIP Eosinophilic granulomatosis with polyangiitis (EGPA) Birt-Hogg-Dubé-Syndrome (Cystic lung disease)
Therapy	Supplemental oxygen therapy

Overview: Core Datasets

DZL Core Dataset
Acute Lung Injury
Asthma and Allergy
Chronic Obstructive Pulmonary Disease (COPD)
Cystic Fibrosis (CF)
Diffuse Parenchymal Lung Disease (DPLD)
Lung Cancer
Lung Transplant (LTx)
Pneumonia
Pulmonary Hypertension (PH)

Contact

Authors
Prof. Dr. Andreas Günther, UGMLC
Prof. Dr. Matthias Griese, CPCM
Central Data Management

Science and Research

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