Sample and Data Processing

Further Information

Scientific Projects within the Framework of the DZL Broad Informed Consent

At the DZL, biosamples and data or image data are collected from patients and healthy subjects for scientific purposes. The collection is based on informed consent forms (Broad Informed Consent) signed by the patients and subjects. To provide this group of people with information, this page includes an overview of the research projects in which the samples and data are used as well as of the research questions addressed in these projects.

If you have any questions related to sample and data processing at the DZL, please contact the DZL Biobank Manager, Dr. Clemens Ruppert (clemens.ruppert@innere.med.uni-giessen.de), or the DZL Central Office (contact@dzl.de).

Notes on using the database

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View list of abbreviations

Project Title	Project Title	Disease Area / Platform		DZL Site	Year	Samples and Data used
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.	17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.	AA	10.1164/rccm.202305-0934OC	ARCN	2024	Biosamples and Data
Parallel detection of multiple biomarkers in a point-of-care-competent device for the prediction of exacerbations in chronic inflammatory lung disease	Parallel detection of multiple biomarkers in a point-of-care-competent device for the prediction of exacerbations in chronic inflammatory lung disease	AA, COPD	10.1038/s41598-024-62784-8	ARCN	2024	Biosamples and Data
Biofilm infections of endobronchial valves in COPD patients after endoscopic lung volume reduction: a pilot study with FISHseq	Biofilm infections of endobronchial valves in COPD patients after endoscopic lung volume reduction: a pilot study with FISHseq	COPD	10.1038/s41598-024-73950-3.	BREATH	2024	Biosamples and Data
Panpipes: a pipeline for multiomic single-cell and spatial transcriptomic data analysis.	Panpipes: a pipeline for multiomic single-cell and spatial transcriptomic data analysis.	DPLD	10.1186/s13059-024-03322-7	CPC-M	2024	Biosamples and Data
An open-source framework for end-to-end analysis of electronic health record data.	An open-source framework for end-to-end analysis of electronic health record data.	DPLD	10.1038/s41591-024-03214-0	CPC-M	2024	Biosamples and Data
Fluorescent Techniques for RNA Detection in Nanoparticles.	Fluorescent Techniques for RNA Detection in Nanoparticles.	DPLD	10.1007/978-1-0716-3918-4_14	CPC-M	2024	Biosamples and Data
Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts.	Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts.	DPLD	10.1183/13993003.01326-2023	CPC-M	2024	Biosamples and Data
Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis.	Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis.	DPLD	10.1172/jci.insight.168889	CPC-M	2024	Biosamples and Data
Cluster-efficient pangenome graph construction with nf-core/pangenome.	Cluster-efficient pangenome graph construction with nf-core/pangenome.	DPLD	10.1093/bioinformatics/btae609	CPC-M	2024	Biosamples and Data
OpenMS 3 enables reproducible analysis of large-scale mass spectrometry data.	OpenMS 3 enables reproducible analysis of large-scale mass spectrometry data.	DPLD	10.1038/s41592-024-02197-7	CPC-M	2024	Biosamples and Data
Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery.	Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery.	DPLD	10.1007/164_2023_703	CPC-M	2024	Biosamples and Data
Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication.	Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication.	DPLD	10.3389/fcimb.2024.1383917	CPC-M	2024	Biosamples and Data
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.	COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.	DPLD	10.1136/thorax-2022-219958	CPC-M	2024	Biosamples and Data
Perioperative Predictive Factors for Tumor Regression and Survival in Non-Small Cell Lung Cancer Patients Undergoing Neoadjuvant Treatment and Lung Resection.	Perioperative Predictive Factors for Tumor Regression and Survival in Non-Small Cell Lung Cancer Patients Undergoing Neoadjuvant Treatment and Lung Resection.	DPLD	10.3390/cancers16162885	CPC-M	2024	Biosamples and Data
Expiratory Venous Volume and Arterial Tortuosity are Associated with Disease Severity and Mortality Risk in Patients with COPD: Results from COSYCONET.	Expiratory Venous Volume and Arterial Tortuosity are Associated with Disease Severity and Mortality Risk in Patients with COPD: Results from COSYCONET.	DPLD	10.2147/COPD.S458905	CPC-M	2024	Biosamples and Data
Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis	Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis	DPLD	10.1101/2024.04.24.589970	UGMLC	2024	Biosamples and Data
Adiponectin suppresses stiffness-dependent, profibrotic activation of lung fibroblasts	Adiponectin suppresses stiffness-dependent, profibrotic activation of lung fibroblasts	DPLD	10.1152/ajplung.00037.2024	UGMLC	2024	Biosamples and Data
It takes two peroxisome proliferator-activated receptors (PPAR-β/δ and PPAR-γ) to tango idiopathic pulmonary fibrosis	It takes two peroxisome proliferator-activated receptors (PPAR-β/δ and PPAR-γ) to tango idiopathic pulmonary fibrosis	DPLD	10.1186/s12931-024-02935-7	UGMLC	2024	Biosamples and Data
Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis.	Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis.	DPLD	10.1172/jci.insight.168889	UGMLC, CPC-M	2024	Biosamples and Data
The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer	The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer	LC	10.1016/j.trsl.2024.02.007	ARCN, TLRC	2024	Biosamples and Data
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens	A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens	LC	10.1186/s12014-024-09501-9	TLRC	2024	Biosamples and Data
Combination of calretinin, MALAT1, and GAS5 as a potential prognostic biomarker to predict disease progression in surgically treated mesothelioma patients	Combination of calretinin, MALAT1, and GAS5 as a potential prognostic biomarker to predict disease progression in surgically treated mesothelioma patients	LC	10.1016/j.lungcan.2024.107802	TLRC	2024	Biosamples and Data
Prognostic value of tumor markers ProGRP, NSE and CYFRA 21-1 in patients with small cell lung cancer and chemotherapy-induced remission	Prognostic value of tumor markers ProGRP, NSE and CYFRA 21-1 in patients with small cell lung cancer and chemotherapy-induced remission	LC	10.3233/TUB-230016	TLRC	2024	Biosamples and Data
Low tumor interleukin-1beta expression predicts a limited effect of adjuvant platinum-based chemotherapy for patients with completely resected lung adenocarcinoma: An identification and validation study	Low tumor interleukin-1beta expression predicts a limited effect of adjuvant platinum-based chemotherapy for patients with completely resected lung adenocarcinoma: An identification and validation study	LC	10.1016/j.pulmoe.2024.03.003	TLRC	2024	Biosamples and Data
Dissecting AI-based mutation prediction in lung adenocarcinoma: A comprehensive real-world study	Dissecting AI-based mutation prediction in lung adenocarcinoma: A comprehensive real-world study	LC	10.1016/j.ejca.2024.114292	TLRC	2024	Data
PITX2 as a Sensitive and Specific Marker of Midgut Neuroendocrine Tumors: Results from a Cohort of 1157 Primary Neuroendocrine Neoplasms	PITX2 as a Sensitive and Specific Marker of Midgut Neuroendocrine Tumors: Results from a Cohort of 1157 Primary Neuroendocrine Neoplasms	LC	10.1016/j.modpat.2024.100442	TLRC	2024	Data
CYFRA 21-1, CA 125 and CEA provide additional prognostic value in NSCLC patients with stable disease at first CT scan	CYFRA 21-1, CA 125 and CEA provide additional prognostic value in NSCLC patients with stable disease at first CT scan	LC	10.3233/TUB-220042	TLRC	2024	Data
Robotic thoracic surgery for neurogenic tumors	Robotic thoracic surgery for neurogenic tumors	LC	10.3171/2024.3.JNS232860	TLRC	2024	Data
CT-guided needle biopsy is not associated with increased ipsilateral pleural metastasis	CT-guided needle biopsy is not associated with increased ipsilateral pleural metastasis	LC	10.1016/j.lungcan.2024.107890	TLRC	2024	Data
Peri- and postoperative morbidity and mortality in older patients with non-small cell lung cancer: a matched-pair study	Peri- and postoperative morbidity and mortality in older patients with non-small cell lung cancer: a matched-pair study	LC	10.1186/s12957-024-03491-6	TLRC	2024	Data
Perip+A27:F36heral Inflammation Featuring Eosinophilia or Neutrophilia Is Associated with the Survival and Infiltration of Eosinophils within the Tumor among Various Histological Subgroups of Patients with NSCLC	Perip+A27:F36heral Inflammation Featuring Eosinophilia or Neutrophilia Is Associated with the Survival and Infiltration of Eosinophils within the Tumor among Various Histological Subgroups of Patients with NSCLC	LC	10.3390/ijms25179552	TLRC, UGMLC	2024	Data
Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation.	Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation.	PALI	10.1007/s00408-024-00679-1	BREATH	2024	Biosamples and Data
A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients	A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients	PALI	10.1038/s41598-024-66288-3	BREATH	2024	Biosamples and Data
A precise performance-based reimbursement model for the multi-centre NAPKON cohorts - development and evaluation	A precise performance-based reimbursement model for the multi-centre NAPKON cohorts - development and evaluation	PALI	10.1038/s41598-024-63945-5	BREATH	2024	Biosamples and Data
Frequency and clinical significance of Herpes simplex virus type 1/2 reactivation in adult patients with mild to moderately severe community-acquired pneumonia: a multicentre cohort study	Frequency and clinical significance of Herpes simplex virus type 1/2 reactivation in adult patients with mild to moderately severe community-acquired pneumonia: a multicentre cohort study	PALI	10.1007/s15010-024-02351-5	BREATH	2024	Biosamples and Data
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation	The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation	PALI	10.1016/j.cell.2024.06.014	BREATH	2024	Biosamples and Data
IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota	IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota	PALI	10.1073/pnas.2310864121	BREATH	2024	Biosamples and Data
Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)-A prospective multicenter study	Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)-A prospective multicenter study	PALI	10.1016/j.jcv.2024.105694	BREATH	2024	Biosamples and Data
Comparison of clinical outcomes in hospitalized patients with COVID-19 or non-COVID-19 community-acquired pneumonia in a prospective observational cohort study	Comparison of clinical outcomes in hospitalized patients with COVID-19 or non-COVID-19 community-acquired pneumonia in a prospective observational cohort study	PALI	10.1007/s15010-024-02292-z	BREATH	2024	Biosamples and Data
Exploring secretory proteome and cytokine kinetic of human peripheral blood mononuclear cells exposed to methicillin-resistant Staphylococcus aureus biofilms and planktonic bacteria	Exploring secretory proteome and cytokine kinetic of human peripheral blood mononuclear cells exposed to methicillin-resistant Staphylococcus aureus biofilms and planktonic bacteria	PALI	10.3389/fimmu.2024	BREATH	2024	Biosamples and Data
Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection	Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection	PALI	10.1128/mbio.03408-23	BREATH	2024	Biosamples and Data
Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses	Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses	PALI	10.1016/j.isci.2024.109330	BREATH	2024	Biosamples and Data
Pathogen spectrum of community-acquired pneumonia in people living with HIV (PLWH) in the German CAPNETZ cohort	Pathogen spectrum of community-acquired pneumonia in people living with HIV (PLWH) in the German CAPNETZ cohort	PALI	10.1007/s15010-023-02070-3	BREATH	2024	Biosamples and Data
Integration of Inventory Data from Cohort and Registry Studies into an Existing Research Network: National Pandemic Cohort Network (NAPKON)	Integration of Inventory Data from Cohort and Registry Studies into an Existing Research Network: National Pandemic Cohort Network (NAPKON)	PALI	10.1055/a-2346-9680	BREATH	2024	Data
GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension	GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension	PH	10.1161/CIRCRESAHA.123.323736	UGMLC	2024	Biosamples and Data
The diverging roles of insulin-like growth factor binding proteins in pulmonary arterial hypertension	The diverging roles of insulin-like growth factor binding proteins in pulmonary arterial hypertension	PH	10.1016/j.vph.2024.107379	UGMLC	2024	Biosamples and Data
Population-Based Biobanking.	Population-Based Biobanking.	PLB	10.3390/genes15010066.	ARCN	2024	n.a.
Data Management in Biobanking: Strategies, Challenges, and Future Directions.	Data Management in Biobanking: Strategies, Challenges, and Future Directions.	PLB	10.3390/biotech13030034	ARCN	2024	n.a.
Effects of Repeated Freeze and Thaw Cycles on the Genome-Wide DNA Methylation Profile of Isolated Genomic DNA	Effects of Repeated Freeze and Thaw Cycles on the Genome-Wide DNA Methylation Profile of Isolated Genomic DNA	PLB	10.1089/bio.2022.0045	BREATH	2024	Biosamples and Data
Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort	Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort	AA	10.1016/j.jaci.2023.01.027	ARCN	2023	Biosamples and Data
Antiviral CD8+ T cell immune responses are impaired by cigarette smoke and in COPD	Antiviral CD8+ T cell immune responses are impaired by cigarette smoke and in COPD	COPD	10.1183/13993003.01374-2022	ARCN	2023	Biosamples and Data
Impact of Coronavirus Disease 2019 on Hospital Admissions, Health Status, and Behavioral Changes of Patients with COPD	Impact of Coronavirus Disease 2019 on Hospital Admissions, Health Status, and Behavioral Changes of Patients with COPD	COPD	10.15326/jcopdf.2022.0383	BREATH	2023	Biosamples and Data
High-resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD	High-resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD	COPD	10.15252/embj.2022111272	TLRC, CPC-M	2023	Biosamples and Data
Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations.	Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations.	COPD	10.1183/13993003.00951-2022	UGMLC	2023	Biosamples and Data
CEACAM6 as a Novel Therapeutic Target to Boost HO-1-mediated Antioxidant Defense in COPD	CEACAM6 as a Novel Therapeutic Target to Boost HO-1-mediated Antioxidant Defense in COPD	COPD	10.1164/rccm.202208-1603OC	UGMLC	2023	Biosamples and Data
Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27.	Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27.	COPD, DPLD	10.1073/pnas.2215421120	UGMLC	2023	Biosamples and Data
Combined Pulmonary Fibrosis and Emphysema: When Scylla and Charybdis	Combined Pulmonary Fibrosis and Emphysema: When Scylla and Charybdis	COPD, DPLD	10.3390/cells12091278.	UGMLC	2023	Biosamples and Data
Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis .	Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis .	COPD, DPLD	10.1164/rccm.202105-1284OC	UGMLC	2023	Biosamples and Data
Fibroblast growth factor 10 reverses cigarette smoke- and elastase-induced emphysema and pulmonary hypertension in mice.	Fibroblast growth factor 10 reverses cigarette smoke- and elastase-induced emphysema and pulmonary hypertension in mice.	COPD, PH	10.1183/13993003.01606-2022	UGMLC	2023	Biosamples and Data
An integrated cell atlas of the lung in health and disease.	An integrated cell atlas of the lung in health and disease.	DPLD	10.1038/s41591-023-02327-2	CPC-M	2023	Biosamples and Data
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.	Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.	DPLD	10.1126/scitranslmed.adh0908	CPC-M	2023	Biosamples and Data
Mass spectrometry-based autoimmune profiling reveals predictive autoantigens in idiopathic pulmonary fibrosis.	Mass spectrometry-based autoimmune profiling reveals predictive autoantigens in idiopathic pulmonary fibrosis.	DPLD	10.1016/j.isci.2023.108345	CPC-M	2023	Biosamples and Data
Antiviral CD8+ T-cell immune responses are impaired by cigarette smoke and in COPD.	Antiviral CD8+ T-cell immune responses are impaired by cigarette smoke and in COPD.	DPLD	10.1183/13993003.01374-2022	CPC-M	2023	Biosamples and Data
Transferability and reproducibility of exposed air-liquid interface co-culture lung models.	Transferability and reproducibility of exposed air-liquid interface co-culture lung models.	DPLD	10.1016/j.impact.2023.100466	CPC-M	2023	Biosamples and Data
Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures.	Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures.	DPLD	10.3389/fimmu.2023.1128239	CPC-M	2023	Biosamples and Data
MRI pulmonary artery flow detects lung vascular pathology in preterms with lung disease.	MRI pulmonary artery flow detects lung vascular pathology in preterms with lung disease.	DPLD	10.1183/13993003.02445-2022	CPC-M	2023	Biosamples and Data
Assessment of Collagen in Translational Models of Lung Research.	Assessment of Collagen in Translational Models of Lung Research.	DPLD	10.1007/978-3-031-26625-6_11	CPC-M	2023	Biosamples and Data
An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast-to-Myofibroblast Differentiation.	An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast-to-Myofibroblast Differentiation.	DPLD	10.1165/rcmb.2022-0159OC	CPC-M	2023	Biosamples and Data
The scverse project provides a computational ecosystem for single-cell omics data analysis.	The scverse project provides a computational ecosystem for single-cell omics data analysis.	DPLD	10.1038/s41587-023-01733-8	CPC-M	2023	Biosamples and Data
Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia.	Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia.	DPLD	10.1038/s41390-022-02093-w	CPC-M	2023	Biosamples and Data
Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.	Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.	DPLD	10.1016/j.bbadis.2022.166592	CPC-M	2023	Biosamples and Data
Targeted GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma.	Targeted GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma.	DPLD	10.1016/j.jconrel.2023.01.014	CPC-M	2023	Biosamples and Data
Single-cell RNA sequencing of human lung innate lymphoid cells in the vascular and tissue niche reveals molecular features of tissue adaptation.	Single-cell RNA sequencing of human lung innate lymphoid cells in the vascular and tissue niche reveals molecular features of tissue adaptation.	DPLD	10.1093/discim/kyad007	CPC-M	2023	Biosamples and Data
Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection.	Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection.	DPLD	10.3389/fmicb.2022.957830	CPC-M	2023	Biosamples and Data
Genetic and geographic influence on phenotypic variation in European sarcoidosis patients	Genetic and geographic influence on phenotypic variation in European sarcoidosis patients	DPLD	10.3389/fmed.2023.1218106	ARCN	2023	Biosamples and Data
The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2	The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2	DPLD	10.1073/pnas.2213715120	ARCN	2023	Biosamples and Data
Differences in Treatment Response in Bronchial Epithelial Cells from Idiopathic Pulmonary Fibrosis (IPF) Patients: A First Step towards Personalized Medicine?	Differences in Treatment Response in Bronchial Epithelial Cells from Idiopathic Pulmonary Fibrosis (IPF) Patients: A First Step towards Personalized Medicine?	DPLD	10.3390/antiox12020443	TLRC	2023	Biosamples and Data
Pericentromeric satellite lncRNAs are induced in cancer- associated fibroblasts and regulate their functions in lung tumorigenesis	Pericentromeric satellite lncRNAs are induced in cancer- associated fibroblasts and regulate their functions in lung tumorigenesis	LC	10.1038/s41419-023-05553-1	UGMLC	2023	Biosamples and Data
Comparison of the sensitivity of different criteria to select lung cancer patients for screening in a cohort of German patients	Comparison of the sensitivity of different criteria to select lung cancer patients for screening in a cohort of German patients	LC	10.1002/cam4.5638	ARCN, BREATH, CPC-M, TLRC, UGMLC	2023	Data
Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma	Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma	LC	10.1038/s41416-023-02284-0	ARCN, TLRC	2023	Biosamples and Data
Early Detection of Lung Cancer Using Small RNAs	Early Detection of Lung Cancer Using Small RNAs	LC	10.1016/j.jtho.2023.07.005	ARCN, TLRC	2023	Biosamples and Data
Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score	Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score	LC	10.1007/s12672-023-00799-9	ARCN, TLRC, UGMLC	2023	Biosamples and Data
Lung Adenocarcinoma Diagnosed at a Younger Age Is Associated with Advanced Stage, Female Sex, and Ever-Smoker Status, in Patients Treated with Lung Resection	Lung Adenocarcinoma Diagnosed at a Younger Age Is Associated with Advanced Stage, Female Sex, and Ever-Smoker Status, in Patients Treated with Lung Resection	LC	10.3390/cancers15082395	TLRC	2023	Data
Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non-Small-Cell Lung Cancer	Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non-Small-Cell Lung Cancer	LC	10.1016/j.cllc.2023.06.013	TLRC, UGMLC	2023	Biosamples and Data
ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth.	ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth.	LC	10.15252/embj.2022111620	UGMLC	2023	Biosamples and Data
Immune mapping of human tuberculosis and sarcoidosis lung granulomas	Immune mapping of human tuberculosis and sarcoidosis lung granulomas	PALI	10.3389/fimmu.2023.1332733	ARCN	2023	Biosamples and Data
A second update on mapping the human genetic architecture of COVID-19.	A second update on mapping the human genetic architecture of COVID-19.	PALI	10.1038/s41586-023-06355-3	ARCN	2023	Biosamples and Data
Genetic Predisposition to Neurological Complications in Patients with COVID-19	Genetic Predisposition to Neurological Complications in Patients with COVID-19	PALI	10.3390/biom13010133	BREATH	2023	Biosamples and Data
Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia	Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia	PALI	10.1183/23120541.00286-2022	BREATH	2023	Biosamples and Data
Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19	Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19	PALI	10.1016/j.xgen.2022.100232	BREATH	2023	Biosamples and Data
Ethical and coordinative challenges in setting up a national cohort study during the COVID-19 pandemic in Germany	Ethical and coordinative challenges in setting up a national cohort study during the COVID-19 pandemic in Germany	PALI	10.1186/s12910-023-00959-0	BREATH	2023	Biosamples and Data
The ratio of neutrophil-to-lymphocyte and platelet-to-lymphocyte and association with mortality in community-acquired pneumonia: a derivation-validation cohort study	The ratio of neutrophil-to-lymphocyte and platelet-to-lymphocyte and association with mortality in community-acquired pneumonia: a derivation-validation cohort study	PALI	10.1007/s15010-023-01992-2	BREATH	2023	Biosamples and Data
Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia	Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia	PALI	10.1183/23120541.00286-2022	BREATH	2023	Biosamples and Data
MicroRNA-223 dampens pulmonary inflammation during pneumococcal pneumonia	MicroRNA-223 dampens pulmonary inflammation during pneumococcal pneumonia	PALI	10.3390/cells12060959	BREATH	2023	Biosamples and Data
Neurofilament light chain levels predict encephalopathy and outcome in community-acquired pneumonia	Neurofilament light chain levels predict encephalopathy and outcome in community-acquired pneumonia	PALI	10.1002/ACN3.51711	BREATH	2023	Biosamples and Data
Is iron deficiency caused by BMPR2 mutations or dysfunction in pulmonary arterial hypertension patients?	Is iron deficiency caused by BMPR2 mutations or dysfunction in pulmonary arterial hypertension patients?	PH	10.1002/pul2.12242	BREATH, TLRC	2023	Biosamples and Data
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.	Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.	PH	10.1161/CIRCRESAHA.122.321836	UGMLC	2023	Biosamples and Data
Trajectories of cough without a cold in early childhood and associations with atopic diseases	Trajectories of cough without a cold in early childhood and associations with atopic diseases	AA	10.1111/cea.14257	CPC-M	2022	Biosamples and Data
IgA+ memory B-cells are significantly increased in patients with asthma and small airway dysfunction	IgA+ memory B-cells are significantly increased in patients with asthma and small airway dysfunction	AA	10.1183/13993003.02130-2021	ARCN	2022	Biosamples and Data
T2-high asthma phenotypes across lifespan	T2-high asthma phenotypes across lifespan	AA	10.1183/13993003.02288-2021	ARCN	2022	Biosamples and Data
Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development	Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development	AA	10.1016/j.jaip.2022.10.035. Epub 2022 Nov 7.	UGMLC	2022	Biosamples and Data
Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells	Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells	CFBE, LC	10.1080/15592294.2021.1959976	TLRC	2022	Biosamples and Data
Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.	Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.	DPLD	10.1016/j.jconrel.2022.09.021	CPC-M	2022	Biosamples and Data
Association of immune cell recruitment and BPD development.	Association of immune cell recruitment and BPD development.	DPLD	10.1186/s40348-022-00148-w	CPC-M	2022	Biosamples and Data
Editorial: Defining and Characterizing Respiratory Disease in an Aging Population.	Editorial: Defining and Characterizing Respiratory Disease in an Aging Population.	DPLD	10.3389/fmed.2022.889834	CPC-M	2022	Biosamples and Data
Emerging Roles of Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis.	Emerging Roles of Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis.	DPLD	10.3390/cells11061050	CPC-M	2022	Biosamples and Data
TRAIL protects the immature lung from hyperoxic injury.	TRAIL protects the immature lung from hyperoxic injury.	DPLD	10.1038/s41419-022-05072-5	CPC-M	2022	Biosamples and Data
Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes.	Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes.	DPLD	10.1016/j.jconrel.2022.03.051	CPC-M	2022	Biosamples and Data
Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia.	Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia.	DPLD	10.1038/s41390-022-02093-w	CPC-M	2022	Biosamples and Data
Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.	Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.	DPLD	10.1016/j.bbadis.2022.166592	CPC-M	2022	Biosamples and Data
Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.	Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.	DPLD	10.1093/nar/gkab1248	CPC-M	2022	Biosamples and Data
Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells.	Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells.	DPLD	10.1152/ajplung.00091.2021	CPC-M	2022	Biosamples and Data
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models.	Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models.	DPLD	10.3389/fcimb.2022.958634	CPC-M	2022	Biosamples and Data
Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects.	Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects.	DPLD	10.3390/pharmaceutics14030671	CPC-M	2022	Biosamples and Data
Activation of immune cell proteasomes in peripheral blood of smokers and COPD patients: implications for therapy.	Activation of immune cell proteasomes in peripheral blood of smokers and COPD patients: implications for therapy.	DPLD	10.1183/13993003.01798-2021	CPC-M	2022	Biosamples and Data
Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant.	Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant.	DPLD	10.1136/thoraxjnl-2021-218083	CPC-M	2022	Biosamples and Data
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.	FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.	DPLD	10.3390/cells11081341	CPC-M	2022	Biosamples and Data
Real-Time Measurement of Cell Mechanics as a Clinically Relevant Readout of an In Vitro Lung Fibrosis Model Established on a Bioinspired Basement Membrane.	Real-Time Measurement of Cell Mechanics as a Clinically Relevant Readout of an In Vitro Lung Fibrosis Model Established on a Bioinspired Basement Membrane.	DPLD	10.1002/adma.202205083	CPC-M	2022	Biosamples and Data
Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection.	Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection.	DPLD	10.3389/fmicb.2022.957830	CPC-M	2022	Biosamples and Data
Differential LysoTracker Uptake Defines Two Populations of Distal Epithelial Cells in Idiopathic Pulmonary Fibrosis.	Differential LysoTracker Uptake Defines Two Populations of Distal Epithelial Cells in Idiopathic Pulmonary Fibrosis.	DPLD	10.3390/cells11020235.	UGMLC	2022	Biosamples and Data
An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea	An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea	DPLD	10.1242/dev.199804	UGMLC	2022	Biosamples and Data
Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis	Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis	DPLD	10.3390/cells11081341	UGMLC	2022	Biosamples and Data
Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis	Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis	DPLD	10.3390/cells11101593	UGMLC	2022	Biosamples and Data
Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis	Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis	DPLD	10.1126/scitranslmed.abe5407	UGMLC	2022	Biosamples and Data
WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme	WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme	DPLD	10.1073/pnas.2201707119	UGMLC	2022	Biosamples and Data
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Cells.	FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Cells.	DPLD	10.3390/cells11081341	UGMLC, CPC-M	2022	Biosamples and Data
Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma	Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma	LC	10.1007/s00262-021-02981-w	ARCN, CPC-M, TLRC	2022	Biosamples and Data
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	LC	10.1186/s13148-022-01387-4	ARCN, TLRC	2022	Biosamples and Data
A blood-based miRNA signature with prognostic value for overall survival in advanced stage non-small cell lung cancer treated with immunotherapy	A blood-based miRNA signature with prognostic value for overall survival in advanced stage non-small cell lung cancer treated with immunotherapy	LC	10.1038/s41698-022-00262-y	ARCN, TLRC	2022	Biosamples and Data
Lung Adenocarcinoma Cell Sensitivity to Chemotherapies: A Spotlight on Lipid Droplets and SREBF1 Gene	Lung Adenocarcinoma Cell Sensitivity to Chemotherapies: A Spotlight on Lipid Droplets and SREBF1 Gene	LC	10.3390/cancers14184454	BREATH, TLRC	2022	Biosamples and Data
Transmembrane serine protease 2 is a prognostic factor for lung adenocarcinoma	Transmembrane serine protease 2 is a prognostic factor for lung adenocarcinoma	LC	10.3892/ijo.2022.5329	BREATH, TLRC	2022	Biosamples and Data
Protocol of the TREASURE study: Thoracic RadiothErapy with Atezolizumab in Small cell lUng canceR Extensive disease - a randomized, open-label, multicenter phase II trial	Protocol of the TREASURE study: Thoracic RadiothErapy with Atezolizumab in Small cell lUng canceR Extensive disease - a randomized, open-label, multicenter phase II trial	LC	10.1186/s12885-022-10074-9	TLRC	2022	Biosamples and Data
Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms	Establishment of a Tissue-Mimicking Surrogate for Pulmonary Lesions to Improve the Development of RFA Instruments and Algorithms	LC	10.3390/biomedicines10051100	TLRC	2022	Biosamples and Data
Identification of NHLRC1 as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS)	Identification of NHLRC1 as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS)	LC	10.3390/ijms231810699	TLRC	2022	Biosamples and Data
Robust subtyping of non-small cell lung cancer whole sections through MALDI mass spectrometry imaging	Robust subtyping of non-small cell lung cancer whole sections through MALDI mass spectrometry imaging	LC	10.1002/prca.202100068	TLRC	2022	Biosamples and Data
Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers	Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers	LC	10.1080/15592294.2021.1878723	TLRC	2022	Biosamples and Data
Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer	Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer	LC	10.1186/s40001-022-00638-7	TLRC	2022	Biosamples and Data
Serum cytokines predict efficacy and toxicity, but are not useful for disease monitoring in lung cancer treated with PD-(L)1 inhibitors	Serum cytokines predict efficacy and toxicity, but are not useful for disease monitoring in lung cancer treated with PD-(L)1 inhibitors	LC	10.3389/fonc.2022.1010660	TLRC	2022	Biosamples and Data
Acute Phase Proteins as Early Predictors for Immunotherapy Response in Advanced NSCLC: An Explorative Study	Acute Phase Proteins as Early Predictors for Immunotherapy Response in Advanced NSCLC: An Explorative Study	LC	10.3389/fonc.2022.772076	TLRC	2022	Biosamples and Data
Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma in Female Smokers and Never Smokers	Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma in Female Smokers and Never Smokers	LC	10.1158/0008-5472.CAN-21-3836	TLRC	2022	Biosamples and Data
Early Assessment of Chemotherapy Response in Advanced Non-Small Cell Lung Cancer with Circulating Tumor DNA	Early Assessment of Chemotherapy Response in Advanced Non-Small Cell Lung Cancer with Circulating Tumor DNA	LC	10.3390/cancers14102479	TLRC	2022	Biosamples and Data
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer	Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer	LC	10.1038/s41588-022-01115-x	TLRC	2022	Data
Multimodal therapy of epithelioid pleural mesothelioma: improved survival by changing the surgical treatment approach	Multimodal therapy of epithelioid pleural mesothelioma: improved survival by changing the surgical treatment approach	LC	10.21037/tlcr-22-199	TLRC	2022	Data
Deep learning for the detection of anatomical tissue structures and neoplasms of the skin on scanned histopathological tissue sections	Deep learning for the detection of anatomical tissue structures and neoplasms of the skin on scanned histopathological tissue sections	LC	10.3389/fonc.2022.1022967	TLRC	2022	Data
Tumour cell budding and spread through air spaces in squamous cell carcinoma of the lung - Determination and validation of optimal prognostic cut-offs	Tumour cell budding and spread through air spaces in squamous cell carcinoma of the lung - Determination and validation of optimal prognostic cut-offs	LC	10.1016/j.lungcan.2022.04.012	TLRC	2022	Data
Cellular dissociation grading on biopsies of pulmonary squamous cell carcinoma provides prognostic information across all stages and is congruent with resection specimen grading	Cellular dissociation grading on biopsies of pulmonary squamous cell carcinoma provides prognostic information across all stages and is congruent with resection specimen grading	LC	10.1002/cjp2.295	TLRC, CPC-M	2022	Biosamples and Data
Surfactant protein A enhances the degradation of LPS-induced TLR4 in primary alveolar macrophages involving Rab7, β-arrestin2, and mTORC1	Surfactant protein A enhances the degradation of LPS-induced TLR4 in primary alveolar macrophages involving Rab7, β-arrestin2, and mTORC1	Other	10.1128/IAI.00250-21	ARCN	2022	Biosamples and Data
Detailed stratified GWAS analysis for severe COVID-19 in four European populations	Detailed stratified GWAS analysis for severe COVID-19 in four European populations	PALI	10.1093/hmg/ddac158	ARCN	2022	Biosamples and Data
Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis	Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis	PALI	10.1021/acsinfecdis.2c00075	ARCN	2022	Biosamples and Data
Detailed stratified GWAS analysis for severe COVID-19 in four European populations	Detailed stratified GWAS analysis for severe COVID-19 in four European populations	PALI	10.1093/hmg/ddac158	BREATH	2022	Biosamples and Data
The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics	The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics	PALI	10.1007/s10654-022-00896-z	BREATH	2022	Biosamples and Data
Plasma markers of COVID-19 severity: a pilot study	Plasma markers of COVID-19 severity: a pilot study	PALI	10.1186/s12931-022-02272-7	BREATH	2022	Biosamples and Data
Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly	Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly	PALI	10.1038/s41467-022-34487-z	BREATH	2022	Biosamples and Data
Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19	Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19	PALI	10.1016/j.isci.2022.103760	BREATH	2022	Biosamples and Data
Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients	Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients	PALI	10.1038/s41597-022-01669-9	BREATH	2022	Biosamples and Data
A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany	A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany	PALI	10.1183/13993003.02432-2021	BREATH	2022	Biosamples and Data
Canine real-time detection of SARS-CoV-2 infections in the context of a mass screening even	Canine real-time detection of SARS-CoV-2 infections in the context of a mass screening even	PALI	10.1136/bmjgh-2022-010276	BREATH	2022	Biosamples and Data
Early post-discharge mortality in CAP: frequency, risk factors and a prediction tool	Early post-discharge mortality in CAP: frequency, risk factors and a prediction tool	PALI	10.1007/s10096-022-04416-	BREATH	2022	Biosamples and Data
The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling	The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling	PALI	10.1016/j.ebiom.2022	BREATH	2022	Biosamples and Data
Comparative Magnitude and Persistence of Humoral SARS-CoV-2 Vaccination Responses in the Adult Population in Germany	Comparative Magnitude and Persistence of Humoral SARS-CoV-2 Vaccination Responses in the Adult Population in Germany	PALI	10.3389/fimmu.2022.828053	BREATH	2022	Biosamples and Data
Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease	Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease	PALI	10.3390/cells11152283	BREATH	2022	Biosamples and Data
Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections	Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections	PALI	10.2807/1560-7917.ES.2022.27.43.2101089	BREATH	2022	Biosamples and Data
Circulating hyaluronic acid signature in CAP and ARDS – the role of pneumolysin in hyaluronic acid shedding	Circulating hyaluronic acid signature in CAP and ARDS – the role of pneumolysin in hyaluronic acid shedding	PALI	10.1016/J.MATBIO.2022.11.003	BREATH	2022	Biosamples and Data
Early post-discharge mortality in CAP: frequency, risk factors and a prediction tool	Early post-discharge mortality in CAP: frequency, risk factors and a prediction tool	PALI	10.1007/s10096-022-04416-5	BREATH	2022	Biosamples and Data
In-hospital mortality of patients with severe bloodstream infection: Only the tip of the iceberg	In-hospital mortality of patients with severe bloodstream infection: Only the tip of the iceberg	PALI	10.1016/S1473-3099(21)00619-8	BREATH	2022	Biosamples and Data
Development and validation of a sensitive and robust multiplex antigen capture assay to quantify Streptococcus pneumoniae serotype-specific capsular polysaccharides in urine	Development and validation of a sensitive and robust multiplex antigen capture assay to quantify Streptococcus pneumoniae serotype-specific capsular polysaccharides in urine	PALI	10.1128/msphere.00114-22	BREATH	2022	Biosamples and Data
Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group	Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group	PALI	10.1186/s12931-022-02117-3	BREATH	2022	Data
Psychometric validation of the German translation of the Quality of Life Questionnaire – Bronchiectasis (QOL-B): Data from the German bronchiectasis registry PROGNOSIS.	Psychometric validation of the German translation of the Quality of Life Questionnaire – Bronchiectasis (QOL-B): Data from the German bronchiectasis registry PROGNOSIS.	PALI	10.3390/jcm11020441	BREATH	2022	Data
Generation of Human Lung Organoid Cultures from Healthy and Tumor Tissue to Study Infectious Diseases	Generation of Human Lung Organoid Cultures from Healthy and Tumor Tissue to Study Infectious Diseases	PALI	10.1128/jvi.00098-22	TLRC	2022	Biosamples
Reduction of BMPR2 mRNA Expression in Peripheral Blood of Pulmonary Arterial Hypertension Patients: A Marker for Disease Severity?	Reduction of BMPR2 mRNA Expression in Peripheral Blood of Pulmonary Arterial Hypertension Patients: A Marker for Disease Severity?	PH	10.3390/genes13050759	TLRC	2022	Biosamples and Data
Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension	Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension	PH	10.1183/13993003.01698-2021.	UGMLC	2022	Biosamples and Data
Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival.	Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival.	PH	10.1161/CIRCRESAHA.121.319100	UGMLC	2022	Biosamples and Data
Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension	Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension	PH	10.1126/scitranslmed.abe5407	UGMLC	2022	Biosamples and Data
Allergen extract- and component-based diagnostics in children of the ALLIANCE asthma cohort	Allergen extract- and component-based diagnostics in children of the ALLIANCE asthma cohort	AA	10.1111/cea.13964	ARCN	2021	Biosamples and Data
Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time	Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time	AA	10.1111/cei.13550	ARCN	2021	Biosamples and Data
Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers	Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers	AA	10.1164/rccm.202106-1458OC	UGMLC	2021	Biosamples and Data
Differential Regulation of Interferon Signaling Pathways in CD4+ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype	Differential Regulation of Interferon Signaling Pathways in CD4+ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype	AA	10.3390/ijms221810144	UGMLC	2021	Biosamples and Data
Versatile workflow for cell type-resolved transcriptional and epigenetic profiles from cryopreserved human lung	Versatile workflow for cell type-resolved transcriptional and epigenetic profiles from cryopreserved human lung	COPD	10.1172/jci.insight.140443	CPC-M, TLRC	2021	Biosamples and Data
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers.	Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers.	DPLD	10.15252/emmm.202012871	CPC-M	2021	Biosamples and Data
Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-Based Protein Profiling.	Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-Based Protein Profiling.	DPLD	10.1021/acs.jproteome.0c00641	CPC-M	2021	Biosamples and Data
Early Changes and Indicators Characterizing Lung Aging in Neonatal Chronic Lung Disease.	Early Changes and Indicators Characterizing Lung Aging in Neonatal Chronic Lung Disease.	DPLD	10.3389/fmed.2021.665152	CPC-M	2021	Biosamples and Data
Hyperoxia/Hypoxia Exposure Primes a Sustained Pro-Inflammatory Profile of Preterm Infant Macrophages Upon LPS Stimulation.	Hyperoxia/Hypoxia Exposure Primes a Sustained Pro-Inflammatory Profile of Preterm Infant Macrophages Upon LPS Stimulation.	DPLD	10.3389/fimmu.2021.762789	CPC-M	2021	Biosamples and Data
Impaired function and delayed regeneration of dendritic cells in COVID-19.	Impaired function and delayed regeneration of dendritic cells in COVID-19.	DPLD	10.1371/journal.ppat.1009742	CPC-M	2021	Biosamples and Data
In silico numerical simulation of ventilator settings during high-frequency ventilation in preterm infants.	In silico numerical simulation of ventilator settings during high-frequency ventilation in preterm infants.	DPLD	10.1002/ppul.25626	CPC-M	2021	Biosamples and Data
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.	Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.	DPLD	10.1172/jci.insight.150862	CPC-M	2021	Biosamples and Data
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung.	Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung.	DPLD	10.1038/s41586-020-03087-6	CPC-M	2021	Biosamples and Data
Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells.	Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells.	DPLD	10.1152/ajplung.00091.2021	CPC-M	2021	Biosamples and Data
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.	Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.	DPLD	10.1038/s41467-021-24730-4	CPC-M	2021	Biosamples and Data
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.	Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.	DPLD	10.1126/sciadv.abb3673	CPC-M	2021	Biosamples and Data
Decellularized Human Lung Scaffolds as Complex Three-Dimensional Tissue Culture Models to Study Functional Behavior of Fibroblasts.	Decellularized Human Lung Scaffolds as Complex Three-Dimensional Tissue Culture Models to Study Functional Behavior of Fibroblasts.	DPLD	10.1007/978-1-0716-1382-5_30	CPC-M	2021	Biosamples and Data
An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices	An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices	DPLD	10.1183/13993003.00221-2020	TLRC	2021	Biosamples and Data
Profibrotic epithelial TGF-beta1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN	Profibrotic epithelial TGF-beta1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN	DPLD	10.1152/ajplung.00444.2019	TLRC	2021	Biosamples and Data
Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis	Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis	DPLD	10.1164/rccm.202012-4423OC	UGMLC	2021	Biosamples and Data
Early identification of disease progression in ALK-rearranged lung cancer using circulating tumor DNA analysis	Early identification of disease progression in ALK-rearranged lung cancer using circulating tumor DNA analysis	LC	10.1038/s41698-021-00239-3	ARCN, TLRC	2021	Biosamples and Data
DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer	DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer	LC	10.1186/s13148-021-01024-6	ARCN, TLRC	2021	Biosamples and Data
Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma	Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma	LC	10.21037/tlcr-20-1168	ARCN, TLRC	2021	Data
Brigatinib versus other second-generation ALK inhibitors as initial treatment of anaplastic lymphoma kinase positive non-small cell lung cancer with deep phenotyping: study protocol of the ABP trial	Brigatinib versus other second-generation ALK inhibitors as initial treatment of anaplastic lymphoma kinase positive non-small cell lung cancer with deep phenotyping: study protocol of the ABP trial	LC	10.1186/s12885-021-08460-w	TLRC	2021	Biosamples and Data
Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies	Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies	LC	10.21037/tlcr-21-32	TLRC	2021	Biosamples and Data
A Phase II Trial of Nivolumab With Chemotherapy Followed by Maintenance Nivolumab in Patients With Pleural Mesothelioma After Surgery: The NICITA Study Protocol	A Phase II Trial of Nivolumab With Chemotherapy Followed by Maintenance Nivolumab in Patients With Pleural Mesothelioma After Surgery: The NICITA Study Protocol	LC	10.1016/j.cllc.2020.10.005	TLRC	2021	Biosamples and Data
Validation of the T Descriptor (TNM-8) in T3N0 Non-Small-Cell Lung Cancer Patients; a Bicentric Cohort Analysis with Arguments for Redefinition	Validation of the T Descriptor (TNM-8) in T3N0 Non-Small-Cell Lung Cancer Patients; a Bicentric Cohort Analysis with Arguments for Redefinition	LC	10.3390/cancers13081812	TLRC	2021	Data
De Novo Versus Secondary Metastatic EGFR-Mutated Non-Small-Cell Lung Cancer	De Novo Versus Secondary Metastatic EGFR-Mutated Non-Small-Cell Lung Cancer	LC	10.3389/fonc.2021.640048	TLRC	2021	Data
A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma	A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma	LC	10.1080/2162402X.2020.1860586	TLRC	2021	Data
Therapeutic and Prognostic Implications of Immune-Related Adverse Events in Advanced Non-Small-Cell Lung Cancer	Therapeutic and Prognostic Implications of Immune-Related Adverse Events in Advanced Non-Small-Cell Lung Cancer	LC	10.3389/fonc.2021.703893	TLRC	2021	Data
Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: First clinical experience	Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: First clinical experience	LC	10.1016/j.lungcan.2021.01.018	TLRC	2021	Data
Prognostic Impact of PD-L1 Expression in pN1 NSCLC: A Retrospective Single-Center Analysis	Prognostic Impact of PD-L1 Expression in pN1 NSCLC: A Retrospective Single-Center Analysis	LC	10.3390/cancers13092046	TLRC	2021	Data
Comprehensive Dissection of Treatment Patterns and Outcome for Patients With Metastatic Large-Cell Neuroendocrine Lung Carcinoma	Comprehensive Dissection of Treatment Patterns and Outcome for Patients With Metastatic Large-Cell Neuroendocrine Lung Carcinoma	LC	10.3389/fonc.2021.673901	TLRC	2021	Data
The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma	The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma	LC	10.1016/j.esmoop.2021.100253	TLRC	2021	Data
Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples	Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples	LC	10.1186/s12885-021-08140-9	TLRC	2021	Data
Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer	Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer	LC	10.1177/1758835921996509	TLRC	2021	Data
Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer	Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer	LC	10.1016/j.esmoop.2021.100254	TLRC	2021	Data
Sarcopenia on preoperative chest computed tomography predicts cancer-specific and all-cause mortality following pneumonectomy for lung cancer: A multicenter analysis	Sarcopenia on preoperative chest computed tomography predicts cancer-specific and all-cause mortality following pneumonectomy for lung cancer: A multicenter analysis	LC	10.1002/cam4.4207	TLRC	2021	Data
Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican	Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican	LC	10.3390/cancers13020208	TLRC, UGMLC	2021	Biosamples and Data
Systematic Analysis of Composition, Interfacial Performance and Effects of Pulmonary Surfactant Preparations on Cellular Uptake and Cytotoxicity of Aerosolized Nanomaterials	Systematic Analysis of Composition, Interfacial Performance and Effects of Pulmonary Surfactant Preparations on Cellular Uptake and Cytotoxicity of Aerosolized Nanomaterials	Other	10.1002/SMSC.202100067	ARCN	2021	Biosamples and Data
Mapping the human genetic architecture of COVID-19	Mapping the human genetic architecture of COVID-19	PALI	10.1038/s41586-021-03767-x	ARCN	2021	Biosamples and Data
COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19	COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19	PALI	10.1038/s41586-021-03767-x	BREATH	2021	Biosamples and Data
Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross reactivity	Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross reactivity	PALI	10.1038/s41467-021-20973-3	BREATH	2021	Biosamples and Data
Discrimination of SARS-CoV-2 Infections From Other Viral Respiratory Infections by Scent Detection Dogs	Discrimination of SARS-CoV-2 Infections From Other Viral Respiratory Infections by Scent Detection Dogs	PALI	10.3389/fmed.2021.749588	BREATH	2021	Biosamples and Data
Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population	Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population	PALI	10.1177/17534259211029996	BREATH	2021	Biosamples and Data
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality	Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality	PALI	10.1172/JCI152386	BREATH	2021	Biosamples and Data
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19	Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19	PALI	10.1016/j.immuni.2021.09.002	BREATH	2021	Biosamples and Data
Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade	Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade	PALI	10.1007/s15010-021-01605-w	BREATH	2021	Biosamples and Data
Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP)	Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP)	PALI	10.1007/s15010-021-01707-5	BREATH	2021	Biosamples and Data
Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)	Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)	PALI	10.1007/s15010-021-01720-8.	BREATH	2021	Biosamples and Data
Interobserver agreement in interpretation of chest radiographs for pediatric community acquired pneumonia: Findings of the pedCAPNETZ-cohort	Interobserver agreement in interpretation of chest radiographs for pediatric community acquired pneumonia: Findings of the pedCAPNETZ-cohort	PALI	10.1002/PPUL.25528	BREATH	2021	Biosamples and Data
Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia	Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia	PALI	10.1136/gutjnl-2020-320876	BREATH	2021	Biosamples and Data
Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade	Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade	PALI	10.1007/s15010-021-01605-w	BREATH	2021	Biosamples and Data
The impact of the SARS-CoV-2 pandemic on the prevalence of respiratory tract pathogens in patients with community-acquired pneumonia in Germany	The impact of the SARS-CoV-2 pandemic on the prevalence of respiratory tract pathogens in patients with community-acquired pneumonia in Germany	PALI	10.1080/22221751.2021.1957402	BREATH	2021	Biosamples and Data
Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia	Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia	PALI	10.1152/ajplung.00162.2021	BREATH	2021	Biosamples and Data
Behandlung von erwachsenen Patienten mit ambulant erworbener Pneumonie – Update 2021	Behandlung von erwachsenen Patienten mit ambulant erworbener Pneumonie – Update 2021	PALI	10.1055/a-1497-0693	BREATH	2021	Biosamples and Data
Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)	Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)	PALI	10.1007/s15010-021-01720-8	BREATH	2021	Biosamples and Data
Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease	Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease	PALI	10.1371/journal.pone.0258684. external academic	UGMLC	2021	Biosamples and Data
Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension	Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension	PH	10.1165/rcmb.2019-0431OC.	UGMLC	2021	Biosamples and Data
Non-invasive ventilation with pursed lips breathing mode for patients with COPD and hypercapnic respiratory failure: A retrospective analysis	Non-invasive ventilation with pursed lips breathing mode for patients with COPD and hypercapnic respiratory failure: A retrospective analysis	COPD	10.1371/journal.pone.0238619	ARCN	2020	Data
Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Rest andDuring Exercise	Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Rest andDuring Exercise	COPD	10.2147/COPD.S217474	BREATH	2020	Biosamples and Data
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.	Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.	DPLD	10.1038/s41467-020-17358-3	CPC-M	2020	Biosamples and Data
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.	Inhibition of LTβR signalling activates WNT-induced regeneration in lung.	DPLD	10.1038/s41586-020-2882-8	CPC-M	2020	Biosamples and Data
Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-Based Protein Profiling.	Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-Based Protein Profiling.	DPLD	10.1021/acs.jproteome.0c00641	CPC-M	2020	Biosamples and Data
Precision 3D-Printed Cell Scaffolds Mimicking Native Tissue Composition and Mechanics.	Precision 3D-Printed Cell Scaffolds Mimicking Native Tissue Composition and Mechanics.	DPLD	10.1002/adhm.202000918	CPC-M	2020	Biosamples and Data
CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases.	CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases.	DPLD	10.1183/13993003.00460-2019	CPC-M	2020	Biosamples and Data
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice	Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice	DPLD	10.1038/s41467-020-15743-6	BREATH, TLRC	2020	Biosamples and Data
Profibrotic epithelial TGF-beta1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN	Profibrotic epithelial TGF-beta1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN	DPLD	10.1152/ajplung.00444.2019	TLRC	2020	Biosamples and Data
Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores	Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores	DPLD	10.1016/j.matbio.2019.12.001	UGMLC	2020	Biosamples and Data
Notch3 Deficiency Attenuates Pulmonary Fibrosis and Impedes Lung-Function Decline.	Notch3 Deficiency Attenuates Pulmonary Fibrosis and Impedes Lung-Function Decline.	DPLD	10.1165/rcmb.2020-0516OC	UGMLC	2020	Biosamples and Data
Comprehensive serial biobanking in advanced NSCLC: feasibility, challenges and perspectives	Comprehensive serial biobanking in advanced NSCLC: feasibility, challenges and perspectives	LC	10.21037/tlcr-20-137	ARCN, CPC-M, TLRC	2020	Biosamples and Data
Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA	Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA	LC	10.1016/j.ebiom.2020.103103	ARCN, TLRC	2020	Biosamples and Data
Novel Liquid Biomarker Panels for A Very Early Response Capturing of NSCLC Therapies in Advanced Stages	Novel Liquid Biomarker Panels for A Very Early Response Capturing of NSCLC Therapies in Advanced Stages	LC	10.3390/cancers12040954	BREATH, TLRC, UGMLC	2020	Biosamples and Data
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically	MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically	LC	10.1038/s41467-020-18372-1	CPC-M, TLRC	2020	Data
Thoracic radiotherapy plus Durvalumab in elderly and/or frail NSCLC stage III patients unfit for chemotherapy - employing optimized (hypofractionated) radiotherapy to foster durvalumab efficacy: study protocol of the TRADE-hypo trial	Thoracic radiotherapy plus Durvalumab in elderly and/or frail NSCLC stage III patients unfit for chemotherapy - employing optimized (hypofractionated) radiotherapy to foster durvalumab efficacy: study protocol of the TRADE-hypo trial	LC	10.1186/s12885-020-07264-8	TLRC	2020	Biosamples and Data
Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenocarcinoma Reveals Predictive Aberrant Methylation in the Promoter Region of the Long Noncoding RNA PLUT: An Exploratory Study	Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenocarcinoma Reveals Predictive Aberrant Methylation in the Promoter Region of the Long Noncoding RNA PLUT: An Exploratory Study	LC	10.1016/j.jtho.2020.03.023	TLRC	2020	Biosamples and Data
A continuous responder algorithm to optimize clinical management of small-cell lung cancer with progastrin-releasing peptide as a simple blood test	A continuous responder algorithm to optimize clinical management of small-cell lung cancer with progastrin-releasing peptide as a simple blood test	LC	10.1177/1010428320958603	TLRC	2020	Biosamples and Data
Circulating Interleukin-4 Is Associated with a Systemic T Cell Response against Tumor-Associated Antigens in Treatment-Naive Patients with Resectable Non-Small-Cell Lung Cancer	Circulating Interleukin-4 Is Associated with a Systemic T Cell Response against Tumor-Associated Antigens in Treatment-Naive Patients with Resectable Non-Small-Cell Lung Cancer	LC	10.3390/cancers12123496	TLRC	2020	Biosamples and Data
Fibroblast Growth Factor-14 Acts as Tumor Suppressor in Lung Adenocarcinomas	Fibroblast Growth Factor-14 Acts as Tumor Suppressor in Lung Adenocarcinomas	LC	10.3390/cells9081755	TLRC	2020	Biosamples and Data
Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies	Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies	LC	10.3390/cancers12123834	TLRC	2020	Data
Risk stratification of EGFR(+) lung cancer diagnosed with panel-based next-generation sequencing	Risk stratification of EGFR(+) lung cancer diagnosed with panel-based next-generation sequencing	LC	10.1016/j.lungcan.2020.08.007	TLRC	2020	Data
Consolidation Immunotherapy After Platinum-Based Chemoradiotherapy in Patients With Unresectable Stage III Non-Small Cell Lung Cancer-Cross-Sectional Study of Eligibility and Administration Rates	Consolidation Immunotherapy After Platinum-Based Chemoradiotherapy in Patients With Unresectable Stage III Non-Small Cell Lung Cancer-Cross-Sectional Study of Eligibility and Administration Rates	LC	10.3389/fonc.2020.586449	TLRC	2020	Data
BAP1 Loss is a Useful Adjunct to Distinguish Malignant Mesothelioma Including the Adenomatoid-like Variant From Benign Adenomatoid Tumors	BAP1 Loss is a Useful Adjunct to Distinguish Malignant Mesothelioma Including the Adenomatoid-like Variant From Benign Adenomatoid Tumors	LC	10.1097/PAI.0000000000000700	TLRC	2020	Data
Protein-altering germline mutations implicate novel genes related to lung cancer development	Protein-altering germline mutations implicate novel genes related to lung cancer development	LC	10.1038/s41467-020-15905-6	TLRC	2020	Data
Insulinoma-associated Protein 1 (INSM1) in Thoracic Tumors is Less Sensitive but More Specific Compared With Synaptophysin, Chromogranin A, and CD56	Insulinoma-associated Protein 1 (INSM1) in Thoracic Tumors is Less Sensitive but More Specific Compared With Synaptophysin, Chromogranin A, and CD56	LC	10.1097/PAI.0000000000000715	TLRC	2020	Data
Immunohistological expression of oestrogen receptor, progesterone receptor, mammaglobin, human epidermal growth factor receptor 2 and GATA-binding protein 3 in non-small-cell lung cancer	Immunohistological expression of oestrogen receptor, progesterone receptor, mammaglobin, human epidermal growth factor receptor 2 and GATA-binding protein 3 in non-small-cell lung cancer	LC	10.1111/his.14203	TLRC	2020	Data
Deep Learning for the Classification of Small-Cell and Non-Small-Cell Lung Cancer	Deep Learning for the Classification of Small-Cell and Non-Small-Cell Lung Cancer	LC	10.3390/cancers12061604	TLRC	2020	Data
Mass Spectrometry Imaging for Reliable and Fast Classification of Non-Small Cell Lung Cancer Subtypes	Mass Spectrometry Imaging for Reliable and Fast Classification of Non-Small Cell Lung Cancer Subtypes	LC	10.3390/cancers12092704	TLRC	2020	Data
Oligoprogressive Non-Small-Cell Lung Cancer under Treatment with PD-(L)1 Inhibitors	Oligoprogressive Non-Small-Cell Lung Cancer under Treatment with PD-(L)1 Inhibitors	LC	10.3390/cancers12041046	TLRC	2020	Data
A Phase II Trial of Nivolumab With Chemotherapy Followed by Maintenance Nivolumab in Patients With Pleural Mesothelioma After Surgery: The NICITA Study Protocol	A Phase II Trial of Nivolumab With Chemotherapy Followed by Maintenance Nivolumab in Patients With Pleural Mesothelioma After Surgery: The NICITA Study Protocol	LC	10.1016/j.cllc.2020.10.005	TLRC	2020	Data
Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer	Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer	LC	10.1016/j.ccell.2020.05.005	TLRC	2020	Data
Paclitaxel for treatment of advanced small cell lung cancer (SCLC): a retrospective study of 185 patients	Paclitaxel for treatment of advanced small cell lung cancer (SCLC): a retrospective study of 185 patients	LC	10.21037/jtd.2019.12.74	TLRC	2020	Data
Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis	Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis	LC	10.3390/cancers12123528	TLRC, UGMLC	2020	Biosamples and Data
Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia.	Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia.	PALI	10.1016/j.vaccine.2019.11.026	BREATH	2020	Biosamples and Data
Rate and predictors of bacteremia in afebrile community-acquired pneumonia	Rate and predictors of bacteremia in afebrile community-acquired pneumonia	PALI	10.1016/j.chest.2019.10.006	BREATH	2020	Biosamples and Data
No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020	No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020	PALI	10.1007/s15010-020-01471-y	BREATH	2020	Biosamples and Data
Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia	Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia	PALI	10.1136/gutjnl-2020-320876	BREATH	2020	Biosamples and Data
Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity	Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity	PALI	10.1128/JVI.00170-20	TLRC	2020	Biosamples
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells	SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells	PALI	10.15252/embj.20105114	TLRC	2020	Biosamples and Data
Shared and distinct mechanisms of fibrosis.	Shared and distinct mechanisms of fibrosis.	DPLD	10.1038/s41584-019-0322-7	CPC-M	2019	Biosamples and Data
Proteasome activator PA200 regulates myofibroblast differentiation.	Proteasome activator PA200 regulates myofibroblast differentiation.	DPLD	10.1038/s41598-019-51665-0	CPC-M	2019	Biosamples and Data
TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.	TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.	DPLD	10.1152/ajplung.00400.2018.	CPC-M	2019	Biosamples and Data
Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling.	Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling.	DPLD	10.3791/58437	CPC-M	2019	Biosamples and Data
Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells	Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells	DPLD	10.1007/s00109-019-01787-9.	UGMLC	2019	Biosamples and Data
Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank	Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank	DPLD	10.3390/jcm8050643	UGMLC	2019	Biosamples and Data
Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension	Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension	PH	10.1073/pnas.1904064116	UGMLC	2019	Biosamples and Data
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension	Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension	PH	10.1038/s41467-019-10135-x.	UGMLC	2019	Biosamples and Data
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis.	Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis.	DPLD	10.1186/s12931-018-0876-y	CPC-M	2018	Biosamples and Data
Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.	Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.	DPLD	10.1152/ajplung.00205.2017	CPC-M	2018	Biosamples and Data
Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease	DPLD	10.1038/s41467-018-06833-7	UGMLC	2018	Biosamples and Data
Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis.	Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis.	DPLD	10.1371/journal.pone.0207915	UGMLC	2018	Biosamples and Data
Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?	Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?	DPLD, PH	10.1152/ajplung.00140.2018	UGMLC	2018	Biosamples and Data
FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis	FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis	PH	10.15252/emmm.201606261	UGMLC	2018	Biosamples and Data
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.	Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.	Other	10.1038/ncomms11626	UGMLC	2016	Biosamples and Data
Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis.	Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis.	DPLD	10.1136/thoraxjnl-2014-206411	CPC-M, UGMLC	2015	Biosamples and Data
Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling	Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling	DPLD	10.1073/pnas.1415111112	UGMLC	2015	Biosamples and Data

Overview: Patients

wdt_ID	Abkürzung	Bedeutung	ID
2	Work Type		1
4	Original	Originalarbeiten mit Peer Review (z. B. Research Paper, Meta-Analyse, Short Communication, Research Letter, Guideline)
6	Review	Originalarbeiten mit begrenztem Peer Review
8	Other	Sonstige Publikationen ohne Peer Review (z. B. Letter to the Editor, Reply, Response, Editorial)
10	Involved site partner(s)		1
12	CAU	Christian-Albrechts-Universität zu Kiel
14	UzL	Universität zu Lübeck
16	FZB	Forschungszentrum Borstel
18	Ghd	LungenClinic Großhansdorf
20	MHH	Medizinische Hochschule Hannover (Hannover Medical School)
22	LUH	Leibniz Universität Hannover
24	ITEM	Fraunhofer-Institut für Toxikologie und Experimentelle Medizin in Hannover
26	JLU	Justus-Liebig-Universität Gießen
28	UMR	Philipps-Universität Marburg
30	MPI-BN	Max-Planck-Institut für Herz- und Lungenforschung in Bad Nauheim
32	UKHD	Universitätsklinikum Heidelberg
34	RKU	Ruprecht-Karls-Universität Heidelberg
36	Thorax	Thoraxklinik am Universitätsklinikum Heidelberg
38	DKFZ	Deutsches Krebsforschungszentrum
40	EMBL	European Molecular Biology Laboratory
42	HMGU	Helmholtz Zentrum München – Deutsches Forschungszentrum für Gesundheit und Umwelt
44	LMU	Ludwig-Maximilians-Universität München
46	KUM	Klinikum der Universität München
48	Assoziierte Partner		1
50	ASK	Asklepios Fachkliniken München-Gauting
52	CAPNETZ	CAPNETZ Stiftung
54	COSYCONET	German COPD and Systemic Consequences – Comorbidities Network
56	NAKO	Nationale Kohorte e. V.
58	PRI	Pneumologisches Forschungsinstitut an der LungenClinic Grosshansdorf GmbH
60	PROGNOSIS	The Prospective German Non-CF-Bronchiectasis Registry
62	PROGRESS	Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Sepsis
64	RKI	Robert Koch-Institut
66	UKSH (Kiel)	Universitätsklinikum Schleswig-Holstein – Campus Kiel
68	UKSH (Lübeck)	Universitätsklinikum Schleswig-Holstein – Campus Lübeck
70	BIH	Berliner Institut für Gesundheitsforschung (Berlin Institut of Health)
72	Involved DZL site(s)		1
74	Assoziierter Partner
76	ARCN	Airway Research Center North
78	BREATH	Biomedical Research in Endstage and Obstructive Lung Disease Hanover
80	CPC-M	Comprehensive Pneumology Center Munich
82	TLRC	Translational Lung Research Center Heidelberg
84	UGMLC	Universities of Giessen and Marburg Lung Center
86	Disease Area(s)		1
88	AA	Asthma and Allergy
92	CFBE	Cystische Fibrose & Bronchiektaseerkrankungen
94	COPD	Chronic Obstructive Pulmonary Disease
96	DPLD	Diffuse Parenchymal Lung Disease
100	General Lung and Other	(Allgemeine Themen wie z. B. Raucherentwöhnung etc.)
102	LC	Lung Cancer
104	PH	Pulmonary Hypertension
106	PLB	Biobanking and Data Management Platform
108	PLI	Imaging Platform
110	PALI	Pneumonia & Acute Lung Injury
111	ROR	Regeneration & Organ Replacement

Further Information

Scientific Projects within the Framework of the DZL Broad Informed Consent

Notes on using the database

DZL Engagements