Asthma is the most prevalent chronic respiratory disease in children and is also very common in adults. Although the clinical manifestations of asthma in children and adults are rather uniform (e.g. wheezing, shortness of breath, and cough), population-based clinical and genetic studies suggest that asthma is not one but many diseases. Thus, a single “one-size-fits-all” treatment approach is unlikely to work to tackle this important health problem. In order to design personalized treatment approaches for asthma patients, there is urgent need to elucidate the particular molecular mechanisms underlying the various types of asthma. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma and Allergy of the DZL.
The ALLIANCE cohort now comprises more than 1,000 patients and healthy subjects aged between six months and 84 years.