Pneumonia and Acute Lung Injury

Acute lower respiratory tract infections represent an increasing public health problem worldwide, resulting in a disease burden greater than that of any other infection with mortality rates unchanged over the past 50 years. Likewise, the lack of any therapeutic treatment for the most devastating clinical course of pulmonary infection, Acute Respiratory Distress Syndrome (ARDS), and an unacceptably high mortality rate, underscore an urgent need for novel, effective therapeutic approaches. Both microbial attack (bacteria, viruses, fungi) and non-microbial inflammatory injury (aspiration, inhalation of toxic gases) may cause Acute Lung Injury (ALI) with severe respiratory failure. The goal of this Disease Area is to decipher the molecular mechanisms underlying the spread of inflammation into the alveoli and to understand the cellular and molecular signaling pathways leading to dissolution of inflammation and repair of the alveolar epithelium integrity. Based on this knowledge, new therapeutic concepts are being developed to attenuate lung tissue damage and promote tissue repair and organ regeneration.

Scientific Coordinators of the Disease Area

Prof. Dr. Tobias Welte (BREATH)
Prof. Dr. Susanne Herold (UGMLC)

Administrative Coordinators of the Disease Area

Dr. Sylvia Weißmann (UGMLC)

Participating DZL Partner Sites


News about Pneumonia and Acute Lung Injury

26. June 2020

Cancer drug cures COVID-19 patient with acute respiratory distress

A successfully treated case at the Marburg University Medical Center is raising hope for a COVID-19 cure: The team has successfully used the cancer drug ruxolitinib for the first time to cure a patient suffering from acute respiratory distress syndrome (ARDS) after infection with the coronavirus SARS-CoV-2.
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18. June 2020

WHO Guidelines Published For COVID-19 Imaging Techniques

With the participation of Prof. Dr. Hans-Ulrich Kauczor, DZL board member, the World Health Organization (WHO) has published advisory guidelines for the application of imaging techniques in COVID-19, the lung disease caused by the coronavirus.
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28. May 2020

How The Coronavirus Damages The Lungs

An international team led by DZL researcher Dr. Danny Jonigk has been able to prove changes in the lung tissue caused by SARS-CoV-2. The findings of the study show a funda-mental difference to lung damage caused by influenza viruses.
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All Pneumonia and Acute Lung Injury news