Lung Cancer (LC)

Lung Cancer is among the most common types of cancer in Germany. The high mortality rate is often due to diagnosis at a late stage: 40 % of Non-Small Cell Lung Cancer (NSCLC) patients present with metastases at the time of diagnosis. Advances in molecular tumor analysis have led to new opportunities to develop targeted therapies that act on specific molecular targets of the cancer cell. Besides chemotherapy and targeted therapy, immunotherapy has gained significance as the third main pillar of systemic therapy. Immune checkpoint inhibitors unmask the cancer cells and enhance the body’s immune response against malignant cells. Today, combined treatment approaches in precision medicine enable the application of the most effective treatment regimen for each patient. However, not all patients respond to targeted therapy or immunotherapy. Therefore, an important research goal is the identification of predictive markers indicating clinical response or potential treatment failure, for example through evidence of genetic tumor material towards biomarker-directed precision medicine.

Scientific Coordinators of the Disease Area

Prof. Dr. Rajkumar Savai (UGMLC)
Prof. Dr. Michael Thomas (TLRC)

Administrative Coordinator of the Disease Area

Dr. Birgit Teucher (TLRC)

Participating DZL Partner Sites


News about Lung Cancer

17. September 2020

New Treatment Option For Resistant Cancer Cells

It seems like a paradox that, of all things, a molecule which renders tumors resistant to can-cer medications also suppresses a mechanism that is vital for the survival of tumor cells. This is what Professor Thorsten Stiewe, DZL scientist, and his colleagues report in Nature Com¬munications.
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5. August 2020

Assembly within the tumor center

Number of macrophages in tumor tissue enables prognosis of lung tumor progression.
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9. June 2020

Re-education of tumor-associated macrophages offers novel immunotherapeutic option for lung cancer

Lung cancer is the leading cause of cancer death for both men and women and accounts for almost 28% of all cancer deaths worldwide.
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All Lung Cancer news