Results recently published confirm the sensitivity of magnetic resonance imaging (MRI) and the lung clearance index (LCI), a measure of abnormal ventilation distribution...
Results recently published in the American Journal of Respiratory and Critical Care Medicine confirm the sensitivity of magnetic resonance imaging (MRI) and the lung clearance index (LCI), a measure of abnormal ventilation distribution, to detect damage to the lung from early infancy. This is the first study to systematically compare both methods from infancy to early adulthood in patients with cystic fibrosis.
“The study results are not only a breakthrough for diagnosis and disease monitoring but these methods allow us to test new preventive therapeutic strategies that we developed over the past few years with minimalizing the burden for our young patients” says DZL Scientist Professor Dr. Marcus Mall, Medical Director of the Department of Translational Pulmonology at the Translational Lung Research Center Heidelberg (TLRC), Head of Pediatric Pulmonology and the Cystic Fibrosis Center.
The research was funded by the German Center for Lung Research (DZL), the Dietmar Hopp Foundation and the German Cystic Fibrosis Foundation (Mukoviszidose e. V.).
Prof. Dr. Marcus Mall
Ärztlicher Direktor Abteilung Translationale Pneumologie
Zentrum für Translationale Lungenforschung Heidelberg und Leiter Sektion Pädiatrische Pneumologie & Allergologie und Mukoviszidose-Zentrum
Zentrum für Kinder- und Jugendmedizin
(DZL site TLRC, Heidelberg) Tel.: 06221 / 56 4502
email: Marcus.Mall@med.uni-heidelberg.de
Stahl M, Wielputz MO, Graeber SY, Joachim C, Sommerburg O, Kauczor HU, Puderbach M, Eichinger M, Mall MA. Comparison of Lung Clearance Index and Magnetic Resonance Imaging for Assessment of Lung Disease in Children With Cystic Fibrosis. Am J Respir Crit Care Med. 2016 Aug 30. [Epub ahead of print] DOI:10.1164/rccm.201604-0893OC
Press Release of the Heidelberg University Hospital (in German)
