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The Cystic Fibrosis (CF) core dataset represents the most important lung research parameters for the disease area.
| Kategorie | Parameter | Value Set | Description |
|---|---|---|---|
| Biometric Data | Gender | ||
| Biometric Data | Age at visit | ||
| Biometric Data | Weight | ||
| Biometric Data | Height | ||
| Biometric Data | BMI | ||
| Smoking History | Smoking Status | ||
| Smoking History | Amount | ||
| Diagnosis | Cystic Fibrosis (CF) | ||
| Diagnosis | PI-CF (Pancreas insufficient) | ||
| Diagnosis | Cystic fibrosis-related disorder | CFTR-RDs refer to a group of diseases associated with CF mutations; do not meet diagnostic criteria for CF | |
| Diagnosis | PS-CF (Pancreas sufficient) | ||
| Diagnosis | Molecular Alteration | ||
| Comorbidities | Comorbidities | ||
| Comorbidities | Pseudomonas | Pseudomonas is a clinically notable and aggressive pathogen, often causing nosocomial infections. | |
| Therapy | Lung transplantation | ||
| Therapy | Liver transplantation | ||
| Therapy | Oxygen longterm therapy | ||
| Therapy | CFTR-Modulator-Therapy | These therapies are designed to correct the malfunctioning protein made by the CFTR gene | |
| Lung Function | sRaw | Specific Airway Resistance | |
| Lung Function | sRaw% | Specific airway resistance as percentage of predicted value (sRaw%) | |
| Lung Function | TLC | Total Lung Capacity: the volume of air in the lungs at maximum inflation | |
| Lung Function | TLC% | Total Lung Capacity as percentage of the predicted value | |
| Lung Function | Rtot% | Total airway resistance as percentage of predicted value | |
| Lung Function | Rtot | Total airway resistance | |
| Lung Function | RV | Residual Volume: the amount of air remaining in the lungs after maximum exhalation | |
| Lung Function | RV% | Residual Volume as percentage of predicted value | |
| Lung Function | FVC | Forced Vital Capacity: the volume of air that can forcibly be blown out after full inspiration | |
| Lung Function | Vcmax | The largest volume a patient can exhale after a full inhalation | |
| Lung Function | FEV1 | Forced Expiratory Volume in 1 second: the volume of air that has been exhaled at the end of the first second of forced expiration | |
| Lung Function | Multiple Breath Washout | LCI | Lung Clearance Index (LCI) measured by multiple breath washout is a sensititve measure of ventilation inhomogeneity |
| Biobank Samples | Blood | The availability of blood samples for a certain patient | |
| Biobank Samples | Bronchoalveolar Lavage Fluid | The availability of Bronchoalveolar Lavage Fluid samples for a certain patient | |
| Biobank Samples | Nose swab (NS) | The availability of nose swab samples for a certain patient | |
| Biobank Samples | Sputum (SP) | The availability of sputum samples for a certain patient | |
| Laboratory values | IgG | A protein produced by plasma cells and lymphocytes and characteristics of these types of cells | |
| Laboratory values | Total IgE | Total IgE plays an important role in causing allergic reactions. | |
| Laboratory values | PsA Alkaline Protease Antibody | P. aeruginosa alkaline protease is produced during keratitis, otitis media, CF, and bacteraemia. | |
| Laboratory values | PsA Elastase Antibody | Elastase is a major virulence factor in P. aeruginosa; it cause tissue damage during infection in the human host. | |
| Laboratory values | PsA Exotoxin A Antibody | Exotoxin A is the most toxic of the numerous extracellular proteins produced by P. aeruginosa. | |
| Laboratory values | Oral glucose tolerance test (oGTT) | oGGT are used to measure how well the body can process a larger amount of sugar. | |
| Imaging | Chest X-ray performed | ||
| Imaging | MRT NNA performed | ||
| Imaging | Ultrasound |
Authors
PD Dr. Anna-Maria Dittrich, BREATH
PD Dr. Lutz Nährlich, UGMLC
PD Dr. Olaf Sommerburg, TLRC
Central Data Management
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