Chronic Obstructive Pulmonary Disease (COPD)

Science and Research

The Chronic Obstructive Pulmonary Disease (COPD) core dataset represents the most important lung research parameters for the disease area.

Kategorie	Parameter	Value Set	Description
Biometric Data	Gender	Diverse Female Male
Biometric Data	Age at visit
Biometric Data	Weight
Biometric Data	Height
Follow-UP	Wie oft haben Sie in den letzten 12 * Monaten eine akute Verschlechterung Ihrer Lungenerkrankung erfahren (stärkere Atemnot, vermehrter oder eitriger Auswurf), d.h. wie oft ging es Ihnen über mehrere Tage deutlich schlechter als sonst, so dass Sie besondere Maßnahmen ergreifen mussten?
Follow-UP	Wie oft mussten Sie deswegen die Notaufnahme aufsuchen oder Ihren Arzt um einen Hausbesuch bitten?
Follow-UP	Wie oft wurden Sie deswegen ins Krankenhaus aufgenommen?
Follow-UP	Wie oft wurden Sie deswegen mit Antibiotika behandelt?
Follow-UP	Wie oft wurden Sie deswegen mit Kortison-Tabletten oder Kortison-Spritzen* behandelt?
Follow-UP	Wie oft ging die Verschlechterung Ihrer Lungenkrankheit nicht so weit, dass eine der vorherig genannten Maßnahmen notwendig wurden, Sie aber die Dosis Ihrer Medikamente erhöht haben?
Follow-UP	Exazerbationen
Diagnosis	Asthma bronchiale (Bronchialasthma, Lungenasthma, allergisches Asthma)
Diagnosis	Chronische Bronchitis (d.h. Husten nachts ohne Erkältung und mit morgendlichem Auswurf an den meisten Tagen, mindestens 3 Monate im Jahr)
Diagnosis	GOLD Klassifikation	1-4,I-IV,A-D
Smoking History	Smoking Status	Ex Smoker Passive Smoker Active Smoker Never Smoker
Smoking History	Amount	Packyears Zigaretten/Tag
Lung Function	Bronchial dilatation performed?		Bronchodilation refers to the effect of lung inflation after the induction of airway smooth muscle tone.
Lung Function	sRaw effective		Specific Airway Resistance
Lung Function	ITGV		Thoracic gas volume; absolute thorakal vol. of gas at any point in time and any level of alveolar pres.
Lung Function	ERV		Expiratory reserve volume; amount of air that can be breathed out after a normal exhalation.
Lung Function	IVC		Maximum amount of air a person can expel from the lungs after a maximum inhalation.
Lung Function	IVC - pre bronchodilatation
Lung Function	IVC - post bronchodilatation
Lung Function	TLC		TLC is the volume of air at maximum inflation.
Lung Function	TLC - pre bronchodilatation
Lung Function	TLC - post bronchodilatation
Lung Function	RV		RV is the amount of air remaining in the lungs after maximum exhalation.
Lung Function	RV - pre bronchodilatation
Lung Function	RV - post bronchodilatation
Lung Function	IC		IC is the volume of air that can be inspired after normal expiration.
Lung Function	DLCO		DLCO is the CO uptake from a single inspiration in a standard time.
Lung Function	DLCO/VA		Krogh factor (KCO) represents the diffusing capacity in the available alveolar spaces.
Lung Function	DLCO/VA - pre bronchodilatation
Lung Function	DLCO/VA - post bronchodilatation
Lung Function	DLCO Hb adj		ATS recommends for the adjustment of DLCO for Hb the equations from Cotes et al.
Lung Function	FEV1		FEV1 is the volume of air exhaled at the end of the first second of forced expiration.
Lung Function	FEV1 - pre bronchodilatation
Lung Function	FEV1 - post bronchodilatation
Lung Function	FVC		FVC is the volume of air that can forcibly be blown out after a full inspiration.
Lung Function	FVC - pre bronchodilatation
Lung Function	FVC - post bronchodilatation
Lung Function	Tiffeneau		A calculated ratio used in the diagnosis of obstructive and restrictive lung disease.
Lung Function	Tiffeneau - post bronchodilatation
Blood Gas Analysis	PaO2		Partial pressure of oxygen in arterial; the amount of dissolved oxygen in the arterial blood
Blood Gas Analysis	PaCO2		Partial pressure of carbon dioxide in arterial blood; the amount of dissolved carbon dioxide gas in arterial blood
Blood Gas Analysis	pH		pH is a measure of the acidity or alkalinity of blood
Blood Gas Analysis	BE		Base Excess; the difference between the observed and the normal buffer base concentration
Laboratory Values	Leukozyten		White blood cells; part of the immune system participating in both the innate and humoral immune responses
Laboratory Values	Hämoglobin		Hb; the oxygen-carrying pigment and predominant protein in the red blood cells
Laboratory Values	Hämatokrit		Hct; measures the volume of red blood cells compared to the total blood volume
Laboratory Values	Neutrophile		Neutrophils are the cells that respond first to any type of infection or wound
Laboratory Values	Neutrophile in Prozent
Laboratory Values	Eosinophile
Laboratory Values	Eosinophile in Prozent
Laboratory Values	Kreatinin in Blut		Creatinine is a waste product generated from the normal wear and tear of muscles of the human body.
Laboratory Values	CRP		C-Reactive Protein (CRP) is produced by the liver, whose level rises in response to inflammation
Laboratory Values	Alpha-1-Antitrypsin		Alpha-1-Antitrypsin (A1AT) is both an endogenous protease inhibitor and an exogenous one used as medication
Laboratory Values	Triglyceride		A neutral fat that is the usual storage form of lipids in animals
Laboratory Values	Gesamt-Cholesterin
Laboratory Values	LDL-Cholesterin		Low-Density-Lipoprotein
Laboratory Values	HDL-Cholesterin		High-Density-Lipoprotein
Laboratory Values	Glukose		Blood glucose level is the amount of glucose present in the blood of a human
Laboratory Values	HBA1c		HbA1c test is used to measure the amount of glycosylated hemoglobin in the blood
Exercise Testing	6MWT distance
Therapy	Medication
Therapy	Sauerstoffgabe
Biobank Samples	Bioproben verfügbar?
Health Questionnaires	SGRQ	Number from 0 to 100	St. George's Respiratory Questionnaire
Health Questionnaires	MRC	MRC Grade 1 MRC Grade 2 MRC Grade 3 MRC Grade 4 MRC Grade 5
Health Questionnaires	CAT	Number from 0 to 40	COPD Assessment Test

Overview: Core Datasets

DZL Core Dataset
Acute Lung Injury
Asthma and Allergy
Chronic Obstructive Pulmonary Disease (COPD)
Cystic Fibrosis (CF)
Diffuse Parenchymal Lung Disease (DPLD)
Lung Cancer
Lung Transplant (LTx)
Pneumonia
Pulmonary Hypertension (PH)

Contact

Authors
Dr. Sandra Söhler, UGMLC
Dr. Heidrun Lingner, BREATH
Prof. Dr. med. Frederik Trinkmann, TLRC
Dr. med. Benjamin Waschki, ARCN
Central Data Management

Science and Research

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