In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity (particularly renal insufficiency). A retrospective, multicentre study of patients who underwent cytoreductive surgery (CRS) with cisplatin-based HITOC was performed. The study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation (GZ: RI 2905/3-1)). Patients (n = 350) with malignant pleural mesothelioma (n = 261; 75%) and thymic tumours with pleural spread (n = 58; 17%) or pleural metastases (n = 31; 9%) were analyzed. CRS was accomplished by pleurectomy/decortication (P/D: n = 77; 22%), extended P/D (eP/D: n = 263; 75%) or extrapleural pneumonectomy (EPP: n = 10; 3%). Patients received cisplatin alone (n = 212; 61%) or cisplatin plus doxorubicin (n = 138; 39%). Low-dose cisplatin (≤125 mg/m(2) BSA) was given in 67% of patients (n = 234), and high-dose cisplatin (>125 mg/m(2) BSA) was given in 33% of patients (n = 116). Postoperative renal insufficiency appeared in 12% of the patients (n = 41), and 1.4% (n = 5) required temporary dialysis. Surgical revision was necessary in 51 patients (15%). In-hospital mortality was 3.7% (n = 13). Patients receiving high-dose cisplatin were 2.7 times more likely to suffer from renal insufficiency than patients receiving low-dose cisplatin (p = 0.006). The risk for postoperative renal failure is dependent on the intrathoracic cisplatin dosage but was within an acceptable range.
- Ried, M.
- Kovács, J.
- Markowiak, T.
- Müller, K.
- Huppertz, G.
- Koller, M.
- Winter, H.
- Klotz, L. V.
- Hatz, R.
- Zimmermann, J.
- Passlick, B.
- Schmid, S.
- Hassan, M.
- Eichhorn, M. E.
- Hofmann, H. S.
Keywords
- Hitoc
- chemoperfusion
- cytoreductive surgery
- hyperthermic intrathoracic chemotherapy
- pleural malignancy
- pleural mesothelioma
