BACKGROUND: Noninvasive tests for pulmonary hypertension (PH) are needed to help select patients for diagnostic right heart catheterization (RHC). CT pulmonary angiography (CTPA) is commonly performed for suspected PH. OBJECTIVE: To assess the utility of CTPA-based cardiac chamber volumetric measurements for diagnosis of PH in comparison with echocardiographic and conventional CTPA parameters, using as reference the 2018 updated hemodynamic definition. METHODS: This retrospective study included 109 patients (median age, 68 years; 72 women, 37 men) who underwent non-gated CTPA, echocardiography, and RHC for workup of suspected PH between August 2013 and February 2016. Two radiologists independently used automated 3D segmentation software to determine volumes of the right ventricle (RV), right atrium (RA), left ventricle (LV), and left atrium (LA), and measured axial diameters of cardiac chambers, main pulmonary artery, and ascending aorta. Interobserver agreement was assessed, and mean values were obtained; one observer repeated volumetric measurements to assess intraobserver agreement. ROC analysis was used to assess diagnostic performance for detection of PH. A multivariable binary logistic regression model was established. RESULTS: A total of 60/109 patients had PH. Intra- and interobserver agreement were excellent for all volume measurements (intraclass correlation coefficients, 0.935-0.999). In patients with, versus without, PH, RV volume was 172.6 versus 118.1 ml, and RA volume was 130.2 versus 77.0 ml (both p<.05). Cardiac chamber measurements with highest AUC for PH were RV/LV volume ratio and RA volume (both 0.791). Significant predictors of PH after adjustment for age, sex, and body surface area included RV volume per 10 ml [odds ratio (OR)=1.21], RA volume per 10 ml (OR=1.27), RV/LV volume ratio (OR=2.91), and RA/LA volume ratio (OR=11.22). Regression analysis yielded a predictive model for PH containing two independent predictors, echocardiographic pulmonary arterial systolic pressure and CTPA-based RA volume; the model had AUC 0.898, sensitivity 83.3%, and specificity 85.7%. CONCLUSION: Automated cardiac chamber volumetry using non-gated CTPA, particularly of the RA, provides incremental utility relative to echocardiographic and conventional CTPA parameters for diagnosis of PH. CLINICAL IMPACT: Automated cardiac chamber volumetry on CTPA may facilitate early nonvinvasive detection of PH, identifying patients warranting further evaluation by RHC.
- Melzig, C.
- Do, T. D.
- Egenlauf, B.
- Fink, M. A.
- Grünig, E.
- Kauczor, H. U.
- Heussel, C. P.
- Rengier, F.
