BACKGROUND: Six-minute walk test (6MWT) is routinely performed in chronic thromboembolic pulmonary hypertension (CTEPH) before pulmonary endarterectomy (PEA). However, the clinical relevance of heart rate response (DeltaHR) and exercise-induced oxygen desaturation (EID) during 6MWT is remaining unknown. METHODS: Patients undergoing PEA in our center between 03/2013-04/2014 were assessed prospectively with hemodynamic and exercise parameters prior to and 1 year post-PEA. Patients with symptomatic chronic thromboembolic disease (mean pulmonary artery pressure (mPAP) <25 mmHg) and clinical relevant obstructive pulmonary disease were excluded. The following definitions were used: DeltaHR = (peak HR - resting HR), percent heart rate reserve (HRR) = (peak HR -rest HR)/(220 - age - rest HR) x 100 and EID = SpO2
Richter, M. J.
Milger, K.
Tello, K.
Stille, P.
Seeger, W.
Mayer, E.
Ghofrani, H. A.
Gall, H.
Keywords
- Aged
- Arterial Pressure
- Chronic Disease
- Echocardiography
- Endarterectomy
- Female
- Germany
- *Heart Rate
- Humans
- Hypertension, Pulmonary/*physiopathology
- Linear Models
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Oxygen Consumption
- Prospective Studies
- Pulmonary Artery/physiopathology
- Thromboembolism/*complications/surgery
- Vascular Resistance
- *Walk Test
- *Chronic thromboembolic pulmonary hypertension
- *Heart rate response
- *Oxygen desaturation
- *Pulmonary endarterectomy
