Science and Research

The Impact of Heat-Not-Burn, E-Cigarettes, and Cigarettes on Small Airway Function

INTRODUCTION: E-cigarettes and heated tobacco products (HTPs) are gaining worldwide significance. The tobacco industry is promoting these products as healthier alternatives to conventional cigarettes. METHODS: In this four-arm crossover study, we examined the acute effects of cigarette smoking, vaping IQOS, or vaping e-cigarettes (with or without nicotine) on hemodynamics, arterial stiffness, and small airways. Twenty subjects (10 male, 10 female), all occasional smokers, completed each study arm. There was at least a 48 h washout period before each test day. Arterial stiffness and peripheral and central hemodynamics were assessed using Mobil-O-Graph™ (I.E.M., Germany), whereas tremoFlo® c-100 (Thoracic Medical Systems Inc) was used to evaluate the effects on the small airways and resistance. RESULTS: Cigarettes, IQOS, e-cigarettes containing nicotine, and nicotine-free e-cigarettes had similar effects on peripheral and central hemodynamics as well as on arterial stiffness. We observed a significant increase in all parameters. However, only nicotine-containing products lead to increased bronchial obstruction, higher reactance, and a higher tidal volume. CONCLUSION: Therefore, we concluded that cigarettes, IQOS, and e-cigarettes have similar effects on hemodynamics. No differences were observed between the nicotine-containing and nicotine-free e-cigarettes. All nicotine-containing products also influence small airways. These findings suggest that e-cigarettes and HTPs are not healthier alternatives than conventional cigarettes.

  • Jung, L.
  • Buchwald, I. C.
  • Hauck, A.
  • Lüthgen, M.
  • Jagomast, T.
  • Weckmann, M.
  • Drömann, D.
  • Franzen, K. F.

Keywords

  • Evali
  • chronic lung disease
  • cigarette
  • electronic cigarette
  • heat-not-burn
  • small airway function
  • small airways
  • smoking
  • tremoflo
Publication details
DOI: 10.1177/1179173x241271551
Journal: Tob Use Insights
Pages: 1179173x241271551 
Work Type: Original
Location: Assoziierter Partner, ARCN
Disease Area: General Lung and Other
Partner / Member: Ghd, FZB, UKSH (Lübeck)
Access-Number: 39314801

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