Echo time-dependent observed T1 and quantitative perfusion in chronic obstructive pulmonary disease using magnetic resonance imaging

INTRODUCTION: Due to hypoxic vasoconstriction, perfusion is interesting in the lungs. Magnetic Resonance Imaging (MRI) perfusion imaging based on Dynamic Contrast Enhancement (DCE) has been demonstrated in patients with Chronic Obstructive Pulmonary Diseases (COPD) using visual scores, and quantification methods were recently developed further. Inter-patient correlations of echo time-dependent observed T(1) [T(1)(TE)] have been shown with perfusion scores, pulmonary function testing, and quantitative computed tomography. Here, we examined T(1)(TE) quantification and quantitative perfusion MRI together and investigated both inter-patient and local correlations between T(1)(TE) and quantitative perfusion. METHODS: 22 patients (age 68.0 ± 6.2) with COPD were examined using morphological MRI, inversion recovery multi-echo 2D ultra-short TE (UTE) in 1-2 slices for T(1)(TE) mapping, and 4D Time-resolved angiography With Stochastic Trajectories (TWIST) for DCE. T(1)(TE) maps were calculated from 2D UTE at five TEs from 70 to 2,300 

• Triphan, S. M. F.
• Konietzke, M.
• Biederer, J.
• Eichinger, M.
• Vogelmeier, C. F.
• Jörres, R. A.
• Kauczor, H. U.
• Heußel, C. P.
• Jobst, B. J.
• Wielpütz, M. O.