Science and Research

Differences between women and men in prolonged weaning

BACKGROUND: In recent years, the importance of sex as a factor influencing medical care has received increasing attention in the field of intensive care medicine. The objective of this study was to examine the influence of sex in prolonged weaning. METHODS: A retrospective analysis of patients undergoing prolonged weaning at Thoraxklinik, University Hospital Heidelberg between 12/08 and 12/23 was conducted. Patients with neuromuscular diseases were excluded from the analyses. The risk factors for weaning failure in men and women were identified through stepwise cox-regression analyses. RESULTS: A total of 785 patients were included, of whom 313 (39.9%) were women. 77.9% of the women and 75.4% of the men were successfully weaned from invasive ventilation. In group comparisons and multivariable analyses, sex was not found to be a risk factor for weaning failure. Cox regression analyses were performed separately for both sexes on the outcome of weaning failure, adjusting for relevant covariates. The results indicated that age 

  • Röser, E.
  • Michels-Zetsche, J. D.
  • Ersöz, H.
  • Neetz, B.
  • Höger, P.
  • Trinkmann, F.
  • Müller, M. M.
  • Klotz, L.
  • Kontogianni, K.
  • Winter, H.
  • Dahlhoff, J. C.
  • Krysa, S.
  • Herth, F. J. F.
  • Trudzinski, F. C.

Keywords

  • Humans
  • Male
  • *Ventilator Weaning/methods
  • Female
  • Retrospective Studies
  • Aged
  • Middle Aged
  • Time Factors
  • Risk Factors
  • Sex Factors
  • Sex Characteristics
  • Aged, 80 and over
  • Invasive mechanical ventilation
  • Prolonged weaning
  • Sex-specific differences
  • Weaning outcome
Publication details
DOI: 10.1186/s12931-024-03002-x
Journal: Respir Res
Pages: 363 
Number: 1
Work Type: Original
Location: TLRC
Disease Area: COPD
Partner / Member: Thorax, UKHD
Access-Number: 39379950

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