We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-4) of the baseline dataset of the COSYCONET COPD cohort were used. The associations with dyspnea, exacerbation history, BODE-Index (cut-off 8000/microL was 2.33 (95% CI: 1.60-3.39, p < 0.0001). In stable COPD, the concentration of oxygenated hemoglobin provided additional information on disease state, especially mortality risk. OxyHem can be calculated from hemoglobin concentration and oxygen saturation without the need for the measurement of PaO2. It thus appears well suited for clinical use with minimal equipment, especially for GPs.
- Trudzinski, F. C.
- Jorres, R. A.
- Alter, P.
- Kahnert, K.
- Waschki, B.
- Herr, C.
- Kellerer, C.
- Omlor, A.
- Vogelmeier, C. F.
- Fahndrich, S.
- Watz, H.
- Welte, T.
- Jany, B.
- Sohler, S.
- Biertz, F.
- Herth, F.
- Kauczor, H. U.
- Bals, R.
- Cosyconet consortium
