Science and Research

Feasibility, Repeatability, and Correlation to Lung Function of Phase-Resolved Functional Lung (PREFUL) MRI-derived Pulmonary Artery Pulse Wave Velocity Measurements

BACKGROUND: Pulse wave velocity (PWV) in the pulmonary arteries (PA) is a marker of vascular stiffening. Currently, only phase-contrast (PC) MRI-based options exist to measure PA-PWV. PURPOSE: To test feasibility, repeatability, and correlation to clinical data of Phase-Resolved Functional Lung (PREFUL) MRI-based calculation of PA-PWV. STUDY TYPE: Retrospective. SUBJECTS: 79 (26 female) healthy subjects (age range 19-78), 58 (24 female) patients with chronic obstructive pulmonary disease (COPD, age range 40-77), 60 (33 female) patients with suspected pulmonary hypertension (PH, age range 28-85). SEQUENCE: 2D spoiled gradient echo, 1.5T. ASSESSMENT: PA-PWV was measured from PREFUL-derived cardiac cycles based on the determination of temporal and spatial distance between lung vasculature voxels using a simplified (sPWV) method and a more comprehensive (cPWV) method including more elaborate distance calculation. For 135 individuals, PC MRI-based PWV (PWV-QA) was measured. STATISTICAL TESTS: Intraclass-correlation-coefficient (ICC) and coefficient of variation (CoV) were used to test repeatability. Nonparametric tests were used to compare cohorts. Correlation of sPWV/cPWV, PWV-QA, forced expiratory volume in 1 sec (FEV(1) ) %predicted, residual volume (RV) %predicted, age, and right heart catheterization (RHC) data were tested. Significance level

  • Wernz, M. M.
  • Voskrebenzev, A.
  • Müller, R. A.
  • Zubke, M.
  • Klime
  • Glandorf, J.
  • Czerner, C.
  • Wacker, F.
  • Olsson, K. M.
  • Hoeper, M. M.
  • Hohlfeld, J. M.
  • Vogel-Claussen, J.

Keywords

  • Copd
  • lung
  • pulmonary circulation
  • pulmonary hypertension
  • pulse wave velocity
Publication details
DOI: 10.1002/jmri.29337
Journal: J Magn Reson Imaging
Work Type: Original
Location: BREATH
Disease Area: COPD
Partner / Member: ITEM, MHH
Access-Number: 38460124

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