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COPD - how age and disease-related factors relate to comorbidities

News 2022-139 EN

Could the numerous comorbidities of COPD be attributed to age or COPD severity? DZL scientists have now explored what role these factors play in patients' health status and prognosis.

The chronic obstructive pulmonary disease COPD is closely associated with a number of concomitant diseases (co-morbidities). This interaction is the subject of the COSYCONET (COPD and Systemic Consequences - Comorbidities Network) registry, which includes nearly 3,000 sufferers and conducts multiple data collections on patients' health status. All DZL sites are participating in COSYCONET.

In a publication published in July 2022, DZL researchers investigated the extent to which concomitant diseases can be attributed either to the severity of COPD or to the age of the patients. In particular, heart failure, coronary artery disease, peripheral arterial disease, hypertension, sleep apnea, diabetes, hyperlipidemia, hyperuricemia, and osteoporosis were examined. For each of these diseases, a pattern of influencing factors could be found. Concomitant disease cannot be attributed exclusively to age or COPD stage. However, heart failure and osteoporosis were found to be mainly negatively influenced by COPD, while hypertension was more dependent on age. In addition, the scientists were able to confirm already known dependencies on gender (e.g., for osteoporosis) and body weight (e.g., for sleep apnea). These results enable physicians to improve the risk assessment for the individual patient and to adapt the individual therapy.


Original publication:

Alter P, Kahnert K, Trudzinski FC, Bals R, Watz H, Speicher T, Söhler S, Andreas S, Welte T, Rabe KF, Wouters EFM, Sassmann-Schweda A, Wirtz H, Ficker JH, Vogelmeier CF, Jörres RA (2022) Disease Progression and Age as Factors Underlying Multimorbidity in Patients with COPD: Results from COSYCONET. Int J Chron Obstruct Pulmon Dis 17: 1703-1713 (Assoziierter Partner, ARCN, BREATH, CPC-M, TLRC, UGMLC)

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