Dominant-negative PSMB10 disrupts immunoproteasome assembly and leads to transient T lymphopenia

Immunoproteasomes are specialized multiprotein proteases that degrade intracellular proteins. Their products serve as peptides for human leukocyte antigen class I presentation playing a key role in antiviral defense and self-tolerance. Monoallelic variants in immunoproteasome genes including proteasome subunit

• Ghosh, S.
• Wang, Y.
• Schultheiss, C.
• Borkhardt, A.
• Dafun, A. S.
• Knipp, L.
• Marwitz, S.
• Ehl, S.
• Soulard, C.
• Haddad, E.
• Dey, D.
• Evans, G.
• Golwala, Z. M.
• Bennstein, S. B.
• Laws, H. J.
• Rohlfs, M.
• Magg, T.
• Binder, M.
• Kreins, A. Y.
• Bousquet, M. P.
• Marcoux, J.
• Klein, C.
• Conn, G. L.
• Meiners, S.
• Hauck, F.