Science and Research

Octopamine modulates the innate immune response in Drosophila melanogaster

BACKGROUND: Octopamine, the functional equivalent of noradrenaline in invertebrates, is a key neuromodulator that also influences immune functions. However, the receptor‑specific roles of octopamine in regulating innate immunity in Drosophila melanogaster remain incompletely understood. METHODS: Using loss‑of‑function mutants for the two major octopamine receptors Oct

  • Uliczka, K.
  • Papenmeier, S.
  • Höschler, B.
  • Wagner, C.
  • Roeder, T.
  • Heine, H.

Keywords

  • Animals
  • *Drosophila melanogaster/immunology/genetics/microbiology
  • *Octopamine/metabolism/immunology
  • *Immunity, Innate
  • Phagocytosis/immunology
  • Hemocytes/immunology
  • Drosophila Proteins/genetics/metabolism
  • Receptors, Biogenic Amine/genetics/metabolism
  • Signal Transduction
  • Drosophila immunity
  • antimicrobial peptide
  • biogenic amine
  • hemocyte
  • octopamine
  • phagocytosis
Publication details
DOI: 10.3389/fimmu.2025.1720126
Journal: Front Immunol
Pages: 1720126 
Work Type: Original
Location: ARCN
Disease Area: PALI
Partner / Member: FZB
Access-Number: 41583465


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