Lung transplantation (LTx) offers life-saving therapy for end-stage lung disease, yet primary graft dysfunction (PGD) and bronchiolitis obliterans syndrome remain major complications, which limit long-term outcomes. The risk of PGD increases with prolonged storage and reperfusion injury. This study investigated the protective effects of cystatin C (CysC), a cysteine protease inhibitor, against PGD, through neutralization of cathepsin B activity. LTx recipients exhibited reduced levels of CysC and greater lung damage reflected by increased
- Verma, H. K.
- Morrone, C.
- Rehm, S. R.
- Jeridi, A.
- Smirnova, N. F.
- Doryab, A.
- Weiß, S. A.
- Dashkevich, A.
- Schmid, O.
- Mümmler, C.
- Gerckens, M.
- Conlon, T. M.
- Hecker, M.
- Kneidinger, N.
- Jenne, D. E.
- Yildirim, AÖ
Keywords
- Animals
- *Cystatin C/pharmacology/metabolism
- Mice
- *Lung Transplantation/adverse effects/methods
- Male
- Primary Graft Dysfunction/prevention & control
- Mice, Inbred C57BL
- Lung/pathology/metabolism/drug effects
- Reperfusion Injury/prevention & control
- Humans
- DNA Damage/drug effects
- Cathepsin B/metabolism
- Histones/metabolism
- Bronchiolitis Obliterans
- Organ Preservation/methods
