Background: This study analyzed the utility of soluble ST2 (sST2) and GDF-15 as biomarkers of right ventricular (RV) function in patients with pulmonary hypertension (PH). Methods: GDF-15 and sST2 serum concentrations were measured in patients with PH (n = 628), dilated cardiomyopathy (n = 31) and left ventricular hypertrophy (n = 47), and in healthy controls (n = 61). Results: Median sST2 and GDF-15 levels in patients with left ventricular hypertrophy were higher than in patients with PH and dilated cardiomyopathy. In tertile analysis GDF-15 >1363 pg/ml and sST2 >38 ng/ml were associated with higher N-terminal pro-brain natriuretic peptide, RV systolic dysfunction, RV-pulmonary arterial uncoupling and hemodynamic impairment. Conclusion: GDF-15 and sST2 are potential biomarkers of RV dysfunction in patients with PH.
- Keranov, S.
- Widmann, L.
- Jafari, L.
- Liebetrau, C.
- Keller, T.
- Troidl, C.
- Kriechbaum, S.
- Voss, S.
- Bauer, P.
- Richter, M. J.
- Tello, K.
- Gall, H.
- Ghofrani, H. A.
- Wiedenroth, C. B.
- Guth, S.
- Seeger, W.
- Hamm, C. W.
- Nef, H.
- Dörr, O.
Keywords
- biomolecules
- chronic thromboembolic pulmonary hypertension
- dilated cardiomyopathy
- fibrosis
- heart failure
- idiopathic pulmonary arterial hypertension
- left ventricular hypertrophy
- right ventricular maladaptation
- right ventricular remodeling
- right ventricular-pulmonary arterial coupling
