Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a lethal condition where expansion of the vascular extracellular matrix contributes to increased pulmonary vascular resistance. Versican, a chondroitin sulfate proteoglycan, is known to accumulate in vascular lesions of PAH and hyaluronan and tenascin-C, binding partners of versican, are elevated in PAH. The specific distribution and localization of versican isoforms, their cleavage products, and binding partners in vascular lesions of PAH had not been studied previously. Versican has five distinct isoforms, V0-V4, identified by the arrangement of its chondroitin-sulfate attachment regions, GAG

• Westöö, C.
• Mutgan, A. C.
• van der Have, O.
• Mead, T. J.
• Ahmed, S.
• Lampei, E.
• Koch, C. D.
• Norvik, C.
• Aspberg, A.
• Bech, M.
• Peruzzi, N.
• Brunnström, H.
• Kwapiszewska, G.
• Rådegran, G.
• Apte, S. S.
• Tran-Lundmark, K.