Progress of personalized medicine of cystic fibrosis in the times of efficient CFTR modulators

BACKGROUND: Cystic fibrosis (CF) is a systemic disorder of exocrine glands that is caused by mutations in the CFTR gene. MAIN BODY: The basic defect in people with CF (pwCF) leads to impaired epithelial transport of chloride and bicarbonate that can be assessed by CFTR biomarkers, i.e. the

• Tümmler, B.
• Pallenberg, S. T.
• Dittrich, A. M.
• Graeber, S. Y.
• Naehrlich, L.
• Sommerburg, O.
• Mall, M. A.