Effect of therapeutic plasma exchange on tissue factor and tissue factor pathway inhibitor in septic shock

BACKGROUND: Coagulopathy is part of the pathological host response to infection in sepsis. Higher plasma concentrations of both tissue factor (TF) and tissue factor pathway inhibitor (TFPI) are associated with occurrence of disseminated intravascular coagulation (DIC), multi-organ dysfunction and increased mortality in patients with sepsis. Currently no treatment approaches specifically targeting this axis are available. We hypothesize that therapeutic plasma exchange (TPE) might limit this coagulopathy by restoring the balance of plasma proteins. METHODS: This was a pooled post-hoc biobank analysis including 51 patients with early (shock onset < 24 h) and severe (norepinephrine dose > 0.4 

• Stahl, K.
• Lehner, G. F.
• Wendel-Garcia, P. D.
• Seeliger, B.
• Pape, T.
• Schmidt, B. M. W.
• Schenk, H.
• Schmitt, J.
• Sauer, A.
• Wild, L.
• Peukert, K.
• Putensen, C.
• Bode, C.
• Joannidis, M.
• David, S.