In respiratory airway epithelial cells, lipopolysaccharide (LPS) treatment induced an enhancement of connexin 26 (Cx26) hemichannel activity shown by dye uptake experiments after siRNA-mediated knock-down of Cx26. This effect was already observed at infection relevant concentrations (
- Lehrich, T.
- Dierks, A.
- Plenge, M.
- Obernolte, H.
- Grieger, K.
- Sewald, K.
- Rodriguez, F.
- Malet, L.
- Braubach, P.
- Bedos-Belval, F.
- Ngezahayo, A.
Keywords
- *Lipopolysaccharides/pharmacology
- *Connexin 26/metabolism/antagonists & inhibitors
- *Epithelial Cells/metabolism/drug effects/cytology
- Humans
- Tight Junctions/metabolism/drug effects
- Cell Line
- *Respiratory Mucosa/metabolism/cytology
- Tumor Necrosis Factor-alpha/metabolism
- Molecular Docking Simulation
- Claudin-4/metabolism
- *Connexins/metabolism
- Airway epithelium
- Barrier function
- Calu-3 cells
- Connexin channels
- lipopolysaccharide
- Cytokine
- Pcls
- Primary cells
