BACKGROUND: The single-inhaler triple combination of beclometasone dipropionate, formoterol fumarate, and glycopyrronium (BDP/FF/G) is available for maintenance therapy of chronic obstructive pulmonary disease (COPD). Cardinal features of COPD are lung hyperinflation and reduced exercise capacity. TRIFORCE aimed to evaluate the effect of BDP/FF/G on lung hyperinflation and exercise capacity in patients with COPD. METHODS: This double-blind, randomised, active- and placebo-controlled, crossover study recruited adults with COPD aged
- Watz, H.
- Kirsten, A. M.
- Ludwig-Sengpiel, A.
- Krüll, M.
- Mroz, R. M.
- Georges, G.
- Varoli, G.
- Charretier, R.
- Cortellini, M.
- Vele, A.
- Galkin, D.
Keywords
- Humans
- *Pulmonary Disease, Chronic Obstructive/drug therapy/physiopathology/diagnosis
- Male
- *Beclomethasone/administration & dosage
- Female
- Double-Blind Method
- *Glycopyrrolate/administration & dosage
- *Formoterol Fumarate/administration & dosage
- Middle Aged
- *Cross-Over Studies
- Administration, Inhalation
- Aged
- *Exercise Tolerance/drug effects/physiology
- *Drug Combinations
- Bronchodilator Agents/administration & dosage
- Lung/drug effects/physiopathology
- Treatment Outcome
- Cycle ergometry
- Dual bronchodilation
- Fixed-dose combination
- Hyperinflation
- Triple therapy