An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma

BACKGROUND: Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signaling to severe asthma. IL-6 cooperates with soluble-IL-6R

• El-Husseini, Z. W.
• Khalenkow, D.
• Lan, A.
• van der Molen, T.
• Brightling, C.
• Papi, A.
• Rabe, K. F.
• Siddiqui, S.
• Singh, D.
• Kraft, M.
• Beghe, B.
• van den Berge, M.
• van Gosliga, D.
• Nawijn, M. C.
• Rose-John, S.
• Koppelman, G. H.
• Gosens, R.