Science and Research

Treatable traits: toward precision medicine of chronic airway diseases

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations". In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.

  • Agusti, A.; Bel, E.; Thomas, M.; Vogelmeier, C.; Brusselle, G.; Holgate, S.; Humbert, M.; Jones, P.; Gibson, P. G.; Vestbo, J.; Beasley, R.; Pavord, I. D.

Keywords

  • Asthma/*drug therapy/immunology/physiopathology
  • Humans
  • Inflammation
  • Phenotype
  • Precision Medicine/*methods
  • Pulmonary Disease, Chronic Obstructive/*drug therapy/immunology/physiopathology
Publication details
DOI: 10.1183/13993003.01359-2015
Journal: The European respiratory journal
Pages: 410-9 
Number: 2
Work Type: Review
Location: UGMLC
Disease Area: AA
Partner / Member: UMR
Access-Number: 26828055
See publication on PubMed

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