It has been shown previously that increased circulating endothelial cells-derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well-known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells-derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T-cells are enhanced in various pulmonary hypertension forms and that endothelial cells-derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life-threatening disorder.
- Kosanovic, D.
- Deo, U.
- Gall, H.
- Selvakumar, B.
- Herold, S.
- Weiss, A.
- Petrovic, A.
- Sydykov, A.
- Ghofrani, H. A.
- Schermuly, R. T.
Keywords
- T-cells
- biomarkers
- endothelial cells
- extracellular vesicles
- pulmonary hypertension