Science and Research

Enhanced circulating levels of CD3 cells-derived extracellular vesicles in different forms of pulmonary hypertension

It has been shown previously that increased circulating endothelial cells-derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well-known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells-derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T-cells are enhanced in various pulmonary hypertension forms and that endothelial cells-derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life-threatening disorder.

  • Kosanovic, D.
  • Deo, U.
  • Gall, H.
  • Selvakumar, B.
  • Herold, S.
  • Weiss, A.
  • Petrovic, A.
  • Sydykov, A.
  • Ghofrani, H. A.
  • Schermuly, R. T.

Keywords

  • T-cells
  • biomarkers
  • endothelial cells
  • extracellular vesicles
  • pulmonary hypertension
Publication details
DOI: 10.1177/2045894019864357
Journal: Pulm Circ
Pages: 2045894019864357 
Number: 3
Work Type: Original
Location: UGMLC
Disease Area: PH
Partner / Member: JLU,MPI-BN
Access-Number: 31250703
See publication on PubMed

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