Science and Research

Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma in Female Smokers and Never Smokers

Single-cell analysis of healthy lung tissue and lung cancer reveals distinct tumor cell populations, including cells with differential immune modulating capacity between smokers and never smokers, which could guide future therapeutic strategies.

  • Trefzer, T. B.
  • Schneider, M. A.
  • Jechow, K.
  • Chua, R. L.
  • Muley, T.
  • Winter, H.
  • Kriegsmann, M.
  • Meister, M.
  • Eils, R.
  • Conrad, C.

Keywords

  • *Adenocarcinoma/pathology
  • *Adenocarcinoma of Lung
  • Female
  • Humans
  • *Lung Neoplasms/pathology
  • Smokers
  • Smoking/adverse effects
Publication details
DOI: 10.1158/0008-5472.Can-21-3836
Journal: Cancer Res
Pages: 3116-3129 
Number: 17
Work Type: Original
Location: Assoziierter Partner, TLRC
Disease Area: LC
Partner / Member: BIH, Thorax
Access-Number: 35819252

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