Nirmatrelvir/ritonavir is an effective antiviral therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Use is not recommended in patients with end-stage renal disease (ESDR) due to a lack of data. We investigated the pharmacokinetics of nirmatrelvir/ritonavir (150 mg/100 mg twice a day) in four patients with ESRD undergoing hemodialysis. Nirmatrelvir peak concentrations ranged from 4,563 to 7,898 ng/mL and declined after hemodialysis. Concentrations were up to 4-fold higher but still within the range known from patients without ESRD, without accumulation of nirmatrelvir after the end of treatment.
- Lingscheid, T.
- Kinzig, M.
- Krüger, A.
- Müller, N.
- Bölke, G.
- Tober-Lau, P.
- Münn, F.
- Kriedemann, H.
- Witzenrath, M.
- Sander, L. E.
- Sörgel, F.
- Kurth, F.
Keywords
- Covid-19
- Paxlovid
- end-stage renal disease
- hemodialysis
- nirmatrelvir/ritonavir
