Prospective association between psychopathological symptoms in childhood and asthma in adolescence: Results from the GINIplus and LISA birth cohort studies

BACKGROUND: Although there is a high co-occurrence of psychopathological symptoms and asthma, longitudinal studies considering asthma endotypes in childhood and adolescence are scarce. Therefore, this study examined the prospective association between psychopathology in childhood and current atopic and non-atopic asthma in adolescents, considering sex and puberty-related characteristics. METHODS: The study includes 3584 participants (1790 females, 1794 males) from two German birth cohort studies, GINIplus and LISA. Psychopathological symptoms at age 10 (M = 10.06, SD = .22) were assessed by parent-reported Strengths and Difficulties Questionnaire (SDQ) and current asthma at age 15 (M = 15.07, SD = .30) was defined as a positive parent-reported medical diagnosis, wheezing, and/or medical treatment against asthma (at least two criteria). Atopic asthma was characterized as current asthma and a positive specific immunoglobulin E (IgE) test (

• Keim, P. M.
• Greimel, E.
• Feldmann, L.
• Piechaczek, C. E.
• Harris, C. P.
• Flexeder, C.
• Berdel, D.
• von Berg, A.
• Koletzko, S.
• Bauer, C. P.
• Schikowski, T.
• Herberth, G.
• Heinrich, J.
• Schulte-Körne, G.
• Standl, M.