Urinary eosinophil-derived neurotoxin is associated with reduced lung function in pediatric asthma

INTRODUCTION: Eosinophil-derived neurotoxin (EDN) is a biomarker for eosinophilic activation. Urinary (u) EDN may allow non-invasive monitoring of asthma, but clinical recommendations are lacking. We assessed the potential of uEDN as a marker of disease activity in pediatric asthma. METHODS: We assessed urine samples of 371 children from the German ALLIANCE study cohort, from which we had: 169 preschool wheezers (<6 years), 80 asthmatics (

• Omony, J.
• Thölken, C.
• Salimi, A.
• Laubhahn, K.
• Illi, S.
• Weckmann, M.
• Grychtol, R.
• Rabe, K. F.
• Thiele, D.
• Foth, S.
• Weber, S.
• Brinkmann, F.
• Kopp, M. V.
• Hansen, G.
• Renz, H.
• von Mutius, E.
• Schaub, B.
• Skevaki, C.