Science and Research

Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study

AIM: Comparing oral and gut microbiome profiles between patients with and without ulcerative mucositis during allogeneic stem cell transplantation (aSCT). MATERIALS AND METHODS: Specimens from oral mucosa, saliva, and stool were collected pre-(T0) and post- (T0 +28d ± 14d) aSCT (T1). Microbiome structure differences were analyzed by 16S-rRNA-gene sequencing, and associations to patients' clinical characteristics were investigated. RESULTS: Ten of 25 included patients developed ulcerations. The

  • Bartha, V.
  • Boutin, S.
  • Schüßler, D. L.
  • Felten, A.
  • Fazeli, S.
  • Kosely, F.
  • Luft, T.
  • Wolff, D.
  • Frese, C.
  • Schoilew, K.

Keywords

  • allogeneic stem cell transplantation
  • microbiome
  • mucositis
  • ulcerations
Publication details
DOI: 10.1111/odi.15246
Journal: Oral Dis
Work Type: Original
Location: Assoziierter Partner, ARCN
Disease Area: General Lung and Other
Partner / Member: UKSH (Lübeck), UzL
Access-Number: 39758049

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