Science and Research

Protective effects of neutrophil serine protease inhibition against ischemia-reperfusion injury in lung or heart transplantation

Transplanted organs are inevitably exposed to ischemia-reperfusion (IR) injury, which is known to cause graft dysfunction. Functional and structural changes that follow IR tissue injury are mediated by neutrophils through the production of oxygen-derived free radicals, as well as from degranulation which entails the release of proteases and other pro-inflammatory mediators. Neutrophil serine proteases (NSPs) are believed to be the principal triggers of post-ischemic reperfusion damage. Extended preservation times for the transplanted donor organ correlate with heightened occurrences of vascular damage and graft dysfunction. Preservation with

  • Korkmaz-Icöz, S.
  • Szabó, G.
  • Gieldon, A.
  • McDonald, P. P.
  • Dashkevich, A.
  • Yildirim, AÖ
  • Korkmaz, B.

Keywords

  • cathepsin C
  • elastase
  • heart
  • inflammation
  • ischemia–reperfusion injury
  • lung
  • neutrophil
  • therapeutic approach
Publication details
DOI: 10.1111/febs.17411
Journal: Febs j
Work Type: Review
Location: CPC-M
Disease Area: ROR
Partner / Member: HMGU
Access-Number: 39854149

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