Science and Research

Diagnostic Accuracy of Lung and Abdominal Ultrasound for Tuberculosis in a German Multicenter Cohort of Patients With Presumed Tuberculosis Disease

BACKGROUND: There is limited evidence on point-of-care ultrasound for tuberculosis (TB), but studies suggest high sensitivity, especially for lung ultrasound (LUS). However, insufficient data are available on specificity of the examination and its generalizability to a broader patient population. AIMS: Our study aimed to establish accuracy for lung, chest, and abdominal ultrasound, individually and in combination, for TB diagnosis. METHODS: We conducted a prospective diagnostic accuracy study among consecutive adult out- and inpatients with probable TB in three German referral hospitals. We applied a comprehensive standardized ultrasound protocol. TB diagnosis was established by a microbiological reference standard including polymerase chain reaction and culture. RESULTS: A total of 102 participants originating from 30 different countries were enrolled. HIV prevalence was 7/99 (7%) and 73/102 (72%) had confirmed TB. TB was limited to the lungs in 15/34 (44%) of refugees and 27/39 (69%) in nonrefugees. Focused assessment with sonography for HIV-associated tuberculosis had a sensitivity of 40% (95% confidence interval [CI], 30-52) and specificity of 55% (95% CI, 38-72). Additional findings, such as small subpleural consolidations on LUS had a high sensitivity (88%; 95% CI, 78-93), but a low specificity (17%; 95% CI, 8-35). Larger consolidations in the lung apices had a sensitivity of 19% (95% CI, 12-30) and a specificity of 97% (95% CI, 83-100). CONCLUSIONS: Our study establishes the first data on LUS performance against a comprehensive reference standard. Overall, our data suggest that ultrasound does not meet the requirements for triage but previously described and novel ultrasound targets in combination could aid in the clinical decision making.Registry: DRKS00026636.

  • Weber, S. F.
  • Wolf, P.
  • Wetzstein, N.
  • Küpper-Tetzel, C.
  • Vehreschild, M.
  • Suárez, I.
  • Rybniker, J.
  • Klingmüller, A.
  • Weber, T.
  • Güttlein, M.
  • Tobian, F.
  • Koeppel, L.
  • Beck, J. S.
  • Wolf, R.
  • Manten, K.
  • Zimmermann, S.
  • Christopher, D. J.
  • Herth, F.
  • Bélard, S.
  • Denkinger, C. M.

Keywords

  • diagnosis
  • lung ultrasound
  • migrant medicine
  • point-of-care ultrasound
  • tuberculosis
Publication details
DOI: 10.1093/ofid/ofae651
Journal: Open Forum Infect Dis
Pages: ofae651 
Number: 12
Work Type: Original
Location: TLRC
Disease Area: PALI
Partner / Member: Thorax, UKHD
Access-Number: 39691283

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