Assessing Human Lung Pharmacokinetics Using Exhaled Breath Particles

Background: It remains challenging to quantify lung pharmacokinetics (PK) of a drug administered and targeted to act in the lung. Exhaled breath particles (PEx), which are generated when collapsed distal airways reopen during inhalation, offer a noninvasive way to access undiluted epithelial lining fluid (ELF). Therefore, it was the aim of this study to investigate whether PK data can be derived from PEx. Methods: Six healthy volunteers received either an inhaled dose (400

• Holz, O.
• Sadiq, M. W.
• Gress, C.
• Struß, N.
• Stomilovic, S.
• Lundqvist, A.
• Hohlfeld, J. M.