Science and Research

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

Kidney fibrosis, characterized by excessive extracellular matrix deposition, is a progressive disease that, despite affecting 10% of the population, lacks specific treatments and suitable biomarkers. This study presents a comprehensive, time-resolved multi-omics analysis of kidney fibrosis using an in vitro model system based on human kidney PDGFR

  • Tuechler, N.
  • Burtscher, M. L.
  • Garrido-Rodriguez, M.
  • Khan, M. M.
  • Türei, D.
  • Tischer, C.
  • Kaspar, S.
  • Schwarz, J. J.
  • Stein, F.
  • Rettel, M.
  • Kramann, R.
  • Savitski, M. M.
  • Saez-Rodriguez, J.
  • Pepperkok, R.

Keywords

  • Extracellular Matrix
  • Kidney Fibrosis
  • Multi-omics
  • Network Modeling
  • Time Points
Publication details
DOI: 10.1038/s44320-025-00116-2
Journal: Mol Syst Biol
Work Type: Original
Location: TLRC
Disease Area: General Lung and Other
Partner / Member: EMBL, RKU, UKHD
Access-Number: 40473842


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