Distinct long-term effects on lung function and airway remodeling in ovalbumin and house dust mite mouse models of experimental asthma

Although mouse models of acute allergic inflammation (AAI) have long been used to study asthma mechanisms, their ability to reproduce human disease remains controversial and long-term studies of chronic asthma remain scarce. We compared lung function and tissue changes in three experimental asthma models after four months of recovery. Using x-ray-based lung function (XLF) analysis, we assessed lung parameters and diaphragm motion, alongside lung expression of

• Markus, M. A.
• Albers, J.
• Alves, F.
• Dullin, C.