Science and Research

Relationship between right and left ventricle function in subjects free of cardiovascular diseases: a population-based MRI study

Right (RV) and left ventricular (LV) volumetric measurements by cardiac magnetic resonance imaging (MRI) are established for assessing systolic and diastolic function, but the role of MRI-derived lung volumes in LV function remains unclear. This study investigated the relationship between RV and LV function, considering lung volumes. In the KORA-MRI cohort, 361 subjects underwent 3 T whole-body MRI. Cardiac functional parameters were measured from cine-steady-state free precession sequences using cvi42. Lung volumes were derived semi-automatically with an in-house algorithm. Linear regression analyses assessed RV-LV relationships, adjusted for age, sex, cardiovascular risk factors, and lung volumes. Among 361 subjects (mean age 56.1 ± 9.1 years; 43% women), RV end-diastolic volume was positively associated with LV end-diastolic (

  • von Krüchten, R.
  • Lorbeer, R.
  • Rospleszcz, S.
  • Peters, A.
  • Karrasch, S.
  • Schulz, H.
  • Bulwer, B. E.
  • Wintergerst, C.
  • Askani, E.
  • Diallo, T. D.
  • Bamberg, F.
  • Schlett, C. L.
  • Mujaj, B.

Keywords

  • Humans
  • Male
  • Female
  • Middle Aged
  • *Magnetic Resonance Imaging/methods
  • *Ventricular Function, Left/physiology
  • Aged
  • *Heart Ventricles/diagnostic imaging/physiopathology
  • *Ventricular Function, Right/physiology
  • Stroke Volume/physiology
  • *Cardiovascular Diseases/physiopathology/diagnostic imaging
  • Lung/diagnostic imaging
  • Magnetic Resonance Imaging, Cine
  • Adult
  • Cardiac function
  • Cardiovascular imaging
  • Epidemiology
  • Lung volumes
  • Magnetic resonance imaging
Publication details
DOI: 10.1038/s41598-025-30588-z
Journal: Sci Rep
Pages: 4110 
Number: 1
Work Type: Original
Location: CPC-M
Disease Area: PLI
Partner / Member: KUM
Access-Number: 41611747


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