Science and Research

Protective effect of interferon type I on barrier function of human airway epithelium during rhinovirus infections in vitro

The airway epithelium provides a crucial barrier against infection with respiratory pathogens. This barrier can be impaired following viral infection, paving the way for bacterial superinfections. Type I interferons (IFNs) are important antiviral mediators, and inhaled formulations of these glycoproteins are considered a potential approach for the treatment of respiratory viral infections. To investigate if type I IFNs can also protect against virus-induced epithelial barrier dysfunction, differentiated primary bronchial epithelial cells were pre-treated with IFN-

  • Boland, H.
  • Endres, A.
  • Kinscherf, R.
  • Schubert, R.
  • Wilhelm, B.
  • Schwarzbach, H.
  • Jonigk, D.
  • Braubach, P.
  • Rohde, G.
  • Bellinghausen, C.

Keywords

  • Humans
  • *Rhinovirus/drug effects/physiology
  • *Picornaviridae Infections/drug therapy/virology
  • *Tight Junctions/metabolism/drug effects
  • *Epithelial Cells/virology/drug effects/metabolism/microbiology
  • *Interferon Type I/metabolism/pharmacology
  • Respiratory Mucosa/virology/drug effects
  • Cells, Cultured
  • Zonula Occludens-1 Protein/metabolism
  • Bronchi/virology/cytology
  • Streptococcus pneumoniae/drug effects
  • Coinfection/microbiology/virology
  • Cilia/drug effects/metabolism
Publication details
DOI: 10.1038/s41598-024-82516-2
Journal: Sci Rep
Pages: 30510 
Number: 1
Work Type: Original
Location: BREATH
Disease Area: PALI
Partner / Member: MHH
Access-Number: 39681656

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