In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock(1) termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion(2) and systemic hyperinflammation(3). The pathogenesis of MIS-C remains largely unknown. Here we show that acute MIS-C is characterized by impaired reactivation of virus-reactive memory T cells, which depends on increased serum levels of the cytokine TGF
- Goetzke, C. C.
- Massoud, M.
- Frischbutter, S.
- Guerra, G. M.
- Ferreira-Gomes, M.
- Heinrich, F.
- von Stuckrad, A. S. L.
- Wisniewski, S.
- Licha, J. R.
- Bondareva, M.
- Ehlers, L.
- Khaldi-Plassart, S.
- Javouhey, E.
- Pons, S.
- Trouillet-Assant, S.
- Ozsurekci, Y.
- Zhang, Y.
- Poli, M. C.
- Discepolo, V.
- Lo Vecchio, A.
- Sahin, B.
- Verboom, M.
- Hallensleben, M.
- Heuhsen, A. I.
- Astudillo, C.
- Espinosa, Y.
- Vial Cox, M. C.
- Dobbs, K.
- Delmonte, O. M.
- Montealegre Sanchez, G. A.
- Magliocco, M.
- Barron, K.
- Danielson, J.
- Petrov, L.
- Unterwalder, N.
- Sawitzki, B.
- Matz, M.
- Lehmann, K.
- Gratopp, A.
- von Bernuth, H.
- Burkhardt, L. M.
- Wiese, N.
- Peter, L.
- Schmueck-Henneresse, M.
- Amini, L.
- Maurer, M.
- Roehmel, J. F.
- Gewurz, B. E.
- Yonker, L. M.
- Witkowski, M.
- Kruglov, A.
- Mall, M. A.
- Su, H. C.
- Ozen, S.
- Radbruch, A.
- Belot, A.
- Durek, P.
- Kallinich, T.
- Mashreghi, M. F.
