SMAD2 linker phosphorylation impacts overall survival, proliferation, TGF

BACKGROUND: We investigated the impact of SMAD2 linker phosphorylation (pSMAD2L) on overall and disease-free survival, signal transduction, as well as cancer-related processes in non-small cell lung cancer (NSCLC). METHODS: We generated A549 cells constitutively lacking pSMAD2L (A549L(sub)) to gain mechanistic insights and stimulated NSCLC cell lines with inhibitors against cell cycle-associated kinases or TGF

• Nitschkowski, D.
• Vierbuchen, T.
• Heine, H.
• Behrends, J.
• Reiling, N.
• Reck, M.
• Rabe, K. F.
• Kugler, C.
• Ammerpohl, O.
• Drömann, D.
• Muley, T.
• Kriegsmann, M.
• Stathopoulos, G. T.
• Arendt, K. A. M.
• Goldmann, T.
• Marwitz, S.