Science and Research

The 'real-life' COPD patient in Germany: The DACCORD study

INTRODUCTION: DACCORD is an ongoing, longitudinal, non-interventional study within the German COPD National Prospective Registry. This manuscript describes the baseline characteristics of the first 5924 participants, recruited between November 2012 and November 2013. METHODS: The main inclusion criteria are a physician diagnosis of COPD, age >/=40 years, and initiating or changing COPD maintenance medication. Data collected included: Demographic and disease characteristics; prescribed medication; symptoms; COPD Assessment Test (CAT); modified Medical Research Council dyspnoea score (mMRC); exacerbations; comorbidities; and forced expiratory volume in 1 s (FEV1). RESULTS: Approximately 60% of the population are male, with mean age of 65.7 years and FEV1 61.6% predicted. On entry to the study the majority of patients reported symptoms, most commonly exertional dyspnoea (85.9%) and cough (65.7%). According to GOLD 2010, 48.6% of patients were classified as GOLD II. GOLD 2011 classification was influenced by the symptoms criterion: 43.7 and 45.3% of patients were classified as GOLD B or D using CAT, compared with 26.4 and 34.0%, respectively, using mMRC. The majority of patients were receiving a LAMA-containing regimen, with 39.4% overall receiving ICS. A total of 78.3% of patients reported at least one comorbidity, most commonly cardiovascular. CONCLUSION: In conclusion, DACCORD is a large, prospective, non-interventional study that provides an informative and intriguing picture of the typical COPD patient in Germany.

  • Worth, H.; Buhl, R.; Criee, C. P.; Kardos, P.; Mailander, C.; Vogelmeier, C.

Keywords

  • Aged
  • Comorbidity
  • Female
  • Forced Expiratory Volume
  • Germany/epidemiology
  • Humans
  • Male
  • Middle Aged
  • Primary Health Care/methods/statistics & numerical data
  • Prospective Studies
  • Pulmonary Disease, Chronic Obstructive/diagnosis/*drug therapy/*epidemiology
  • Registries
  • Severity of Illness Index
  • Spirometry/methods
  • Treatment Outcome
  • Baseline
  • Copd
  • Observational
  • Registry
Publication details
DOI: 10.1016/j.rmed.2015.12.010
Journal: Respiratory medicine
Pages: 64-71 
Work Type: Original
Location: UGMLC
Disease Area: COPD
Partner / Member: UMR
Access-Number: 26775251
See publication on PubMed

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