Comparative sensitivity of early cystic fibrosis lung disease detection tools in school aged children

BACKGROUND: Effective detection of early lung disease in cystic fibrosis (CF) is critical to understanding early pathogenesis and evaluating early intervention strategies. We aimed to compare ability of several proposed sensitive functional tools to detect early CF lung disease as defined by CT structural disease in school aged children. METHODS: 50 CF subjects (mean±SD 11.2 ± 3.5y, range 5-18y) with early lung disease (FEV(1)

• Bayfield, K. J.
• Weinheimer, O.
• Middleton, A.
• Boyton, C.
• Fitzpatrick, R.
• Kennedy, B.
• Blaxland, A.
• Jayasuriya, G.
• Caplain, N.
• Wielpütz, M. O.
• Yu, L.
• Galban, C. J.
• Robinson, T. E.
• Bartholmai, B.
• Gustafsson, P.
• Fitzgerald, D.
• Selvadurai, H.
• Robinson, P. D.