Enriched blood IgG sialylation attenuates IgG-mediated and IgG-controlled-IgE-mediated allergic reactions

Murine blood IgG1, but not IgG2a, sialylation levels attenuate IgG-mediated and IgG-controlled IgE-mediated allergic reactions by enhancing the expression of the IgG inhibitory Fcgamma receptor IIB on immune cells, accordingly, human blood IgG sialylation levels correlate with FcgammaRIIB expression.

• Petry, J.
• Rahmoller, J.
• Duhring, L.
• Lilienthal, G. M.
• Lehrian, S.
• Buhre, J. S.
• Bartsch, Y. C.
• Epp, A.
• Lunding, H. B.
• Moremen, K. W.
• Leliavski, A.
• Ehlers, M.