Science and Research

Identification of S-adenosyl-l-homocysteine hydrolase from banana fruit as a novel plant panallergen

Banana allergy is often associated with the pollen and latex allergies, which led us to the hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-l-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons, while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting 

  • Đurašinović, T.
  • Lopandić, Z.
  • Protić-Rosić, I.
  • Nešić, A.
  • Trbojević-Ivić, J.
  • Jappe, U.
  • Gavrović-Jankulović, M.

Keywords

  • Banana
  • Cross-reactivity
  • Epitope mapping
  • Food allergy
  • Panallergen
  • Recombinant allergen
Publication details
DOI: 10.1016/j.foodchem.2023.137782
Journal: Food Chem
Pages: 137782 
Number: Pt 1
Work Type: Original
Location: ARCN
Disease Area: AA
Partner / Member: FZB
Access-Number: 37871426

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