BACKGROUND: Chronic obstructive pulmonary disease (COPD) is caused by interactions between many factors across the life course, including genetics. A proportion of COPD may be due to reduced lung growth in childhood. We hypothesized that a polygenic risk score (PRS) for COPD is associated with lower lung function already in childhood and up to adulthood. METHODS: A weighted PRS was calculated based on the 82 association signals (p
- Hernandez-Pacheco, N.
- Kilanowski, A.
- Kumar, A.
- Curtin, J. A.
- Olvera, N.
- Kress, S.
- Bertels, X.
- Lahousse, L.
- Bhatta, L.
- Granell, R.
- Marí, S.
- Bilbao, J. R.
- Sun, Y.
- Tingskov Pedersen, C. E.
- Karramass, T.
- Thiering, E.
- Dardani, C.
- Kebede Merid, S.
- Wang, G.
- Hallberg, J.
- Koch, S.
- Garcia-Aymerich, J.
- Esplugues, A.
- Torrent, M.
- Ibarluzea, J.
- Lowe, L.
- Simpson, A.
- Gehring, U.
- Vermeulen, R. C. H.
- Roberts, G.
- Bergström, A.
- Vonk, J. M.
- Felix, J. F.
- Duijts, L.
- Bønnelykke, K.
- Timpson, N.
- Brusselle, G.
- Brumpton, B. M.
- Langhammer, A.
- Turner, S.
- Holloway, J. W.
- Arshad, S. H.
- Ullah, A.
- Custovic, A.
- Cullinan, P.
- Murray, C. S.
- van den Berge, M.
- Kull, I.
- Schikowski, T.
- Wedzicha, J. A.
- Koppelman, G.
- Faner, R.
- Agustí, À
- Standl, M.
- Melén, E.
Keywords
- Chronic obstructive pulmonary disease
- Genetics
- Lung function
- Polygenic risk score
