Effective pulmonary messenger RNA (mRNA) vaccination requires delivery systems capable of overcoming the airway barrier and efficiently transfecting pulmonary antigen-presenting cells. Here, we developed a hybrid polymeric system incorporating poly(lactic-co-glycolic) acid (PLGA) and poly(
- Jiang, M.
- Sieber-Schäfer, F.
- Carneiro, S. P.
- Matzek, D.
- Nguyen, A.
- Porras-Gonzalez, D. L.
- Verma, A. K.
- Kolog-Gulko, M.
- Jürgens, D. C.
- Burgstaller, G.
- Popper, B.
- Sun, X.
- Merkel, O. M.
Keywords
- air-liquid interface
- dendritic cells
- endosomal escape
- human precision-cut lung slices
- mRNA release
- messenger RNA vaccine
- poly(beta-amino esters)
- poly(lactic-co-glycolic) acid
- pulmonary delivery
